Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | MyBioSource MBS2010932 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Prostaglandin E Synthase, Microsomal (PTGES)

catalog :

MBS2010932

quantity :

0.01 mg

price :

135 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2010932

products type :

Recombinant Protein

products full name :

Recombinant Prostaglandin E Synthase, Microsomal (PTGES)

products short name :

[Prostaglandin E Synthase, Microsomal (PTGES)]

other names :

[prostaglandin E synthase; Prostaglandin E synthase; prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1; prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein]

products gene name :

[PTGES]

other gene names :

[PTGES; PTGES; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1; MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1]

uniprot entry name :

PTGES_HUMAN

host :

E Coli

purity :

> 90%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.

concentration :

Original Concentration: 200 ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Thr21~Ala148. Tags: N-terminal His and GST Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Predicted isoelectric point: 9.6. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

4758910

ncbi acc num :

NP_004869.1

ncbi gb acc num :

NM_004878.4

uniprot acc num :

O14684

ncbi mol weight :

Predicted: 44.6 kDa. Accurate: 44kDa as determined by SDS-PAGE reducing conditions.

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Eicosanoid Synthesis Pathway (198888); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway (730333)

ncbi summary :

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

uniprot summary :

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. Protein type: Nuclear envelope; EC 5.3.99.3; Membrane protein, integral; Isomerase; Membrane protein, multi-pass; Lipid Metabolism - arachidonic acid. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: endoplasmic reticulum membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; integral to membrane. Molecular Function: glutathione binding; prostaglandin-E synthase activity. Biological Process: chronic inflammatory response; response to retinoic acid; cyclooxygenase pathway; response to lipopolysaccharide; signal transduction; prostaglandin biosynthetic process; response to organic cyclic substance; prostaglandin metabolic process; negative regulation of cell proliferation; response to cytokine stimulus; arachidonic acid metabolic process; response to calcium ion; acute inflammatory response

size1 :

0.01 mg

price1 :

135 USD

size2 :

0.05 mg

price2 :

250

size3 :

0.1 mg

price3 :

375

size4 :

0.2 mg

price4 :

460

size5 :

0.5 mg

price5 :

890

size6 :

1 mg

price6 :

1315

more info or order :

MyBioSource product webpage