Recombinant Interferon Gamma Receptor 1 (IFNgR1) | MyBioSource MBS2010811 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Interferon Gamma Receptor 1 (IFNgR1)

catalog :

MBS2010811

quantity :

0.01 mg

price :

130 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2010811

products type :

Recombinant Protein

products full name :

Recombinant Interferon Gamma Receptor 1 (IFNgR1)

products short name :

Interferon Gamma Receptor 1 (IFNgR1)

other names :

interferon gamma receptor 1; Interferon gamma receptor 1; interferon gamma receptor 1; IFN-gamma-R1; INF-g receptor; IFN-gamma receptor 1; interferon-gamma receptor 1; interferon gamma receptor 1

products gene name :

IFNgR1

other gene names :

Ifngr1; Ifngr1; Ifgr; CD119; Ifngr; Nktar; IFN-gammaR; Ifngr; IFN-gamma receptor 1

uniprot entry name :

INGR1_MOUSE

host :

E Coli

sequence length :

477

sequence :

The sequence of the target protein is listed below. GSGALTST EDPEPPSVPV PTNVLIKSYN LNPVVCWEYQ NMSQTPIFTV QVKVYSGSWT DSCTNISDHC CNIYEQIMYP DVSAWARVKA KVGQKESDYA RSKEFLMCLK GKVGPPGLEI RRKKEEQLSV LVFHPEVVVN GESQGTMFGD GSTCYTFDYT VYVEHNRSGE ILHTKHTVEK EECNETLCEL NISVSTLDSR YCISVDGISS FWQVRTEKSK DVCIPPFHDD RKD

purity :

> 95%

form :

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 Degree C for one month. Aliquot and store at -80 Degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 Degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP) . (May be suitable for use in other assays to be determined by the end user.)

other info1 :

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Gly23~Asp253 (Accession # P15261) with N-terminal His-Tag. Predicted isoelectric point: 5.4. Usage: Reconstitute in ddH2O.

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

6754306

ncbi acc num :

NP_034641.1

ncbi gb acc num :

NM_010511.2

uniprot acc num :

P15261

ncbi mol weight :

52.6kDa

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (926145); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); HIF-1 Signaling Pathway (695223); Herpes Simplex Infection Pathway (377874); Herpes Simplex Infection Pathway (377865); Immune System Pathway (926012); Inflammatory Bowel Disease (IBD) Pathway (842778)

uniprot summary :

IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family. Protein type: Receptor, cytokine; Membrane protein, integral. Cellular Component: membrane; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; integral to membrane; vesicle. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; cytokine binding. Biological Process: cytokine and chemokine mediated signaling pathway

size1 :

0.01 mg

price1 :

130 USD

size2 :

0.05 mg

price2 :

240

size3 :

0.1 mg

price3 :

360

more info or order :

MyBioSource product webpage