product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Single Ig IL1 Related Receptor (SIGIRR)
catalog :
MBS2010695
quantity :
0.01 mg
price :
185 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2010695
products type :
Recombinant Protein
products full name :
Recombinant Single Ig IL1 Related Receptor (SIGIRR)
products short name :
Single Ig IL1 Related Receptor (SIGIRR)
other names :
single Ig IL-1-related receptor; Single Ig IL-1-related receptor; single Ig IL-1-related receptor; TIR8; toll/interleukin-1 receptor 8; single Ig IL-1R-related molecule; single immunoglobulin domain-containing IL1R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8
products gene name :
SIGIRR
other gene names :
Sigirr; Sigirr; RGD1306732; TIR8
uniprot entry name :
SIGIR_RAT
host :
E Coli
sequence length :
409
sequence :
The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSGSEF-MAGVCDRVPN FLSPSEDQAL GPALGSAVAL NCTAWVFSRP QCPQPSVQWL KDGLALGNGS HFSLHQDFWV SDNFSEIVSS VLVFNLTKAE DYGTFTCSAW NVSSHSFTLW RAGPAGHV
purity :
> 95%
form :
Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
storage stability :
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
tested application :
SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
other info1 :
Organism: Rattus norvegicus (Rat). Expression System: Prokaryotic expression. Residues: Met1~Val118 (Accession # Q4V892) with N-terminal His-Tag
other info2 :
Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
products description :
About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.
ncbi gi num :
67846050
ncbi acc num :
NP_001020058.1
ncbi gb acc num :
NM_001024887.1
uniprot acc num :
Q4V892
ncbi mol weight :
14.3kDa
uniprot summary :
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP . By similarity. Subunit structure: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3 . By similarity. Subcellular location: Membrane; Single-pass type III membrane protein . Potential. Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 TIR domain.
size1 :
0.01 mg
price1 :
185 USD
size2 :
0.05 mg
price2 :
385
size3 :
0.1 mg
price3 :
595
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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