protein

Recombinant Dickkopf Related Protein 2 (DKK2)

MBS2010694

0.01 mg

160 USD

Recombinant Protein

Recombinant Dickkopf Related Protein 2 (DKK2)

[Dickkopf Related Protein 2 (DKK2)]

[dickkopf-related protein 2; Dickkopf-related protein 2; dickkopf-related protein 2; hDkk-2; dickkopf-2; dickkopf 2 homolog; dickkopf homolog 2; dickkopf related protein-2; dickkopf WNT signaling pathway inhibitor 2]

[DKK2]

[DKK2; DKK2; DKK-2; Dickkopf-2; Dkk-2; hDkk-2]

DKK2_HUMAN

E Coli

> 97%

Original Concentration: 200 ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Asp159~Lys258. Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Predicted isoelectric point: 9.1. Predicted Molecular Mass: 12.9kDa. Accurate Molecular Mass: 10kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

7657023

NP_055236.1

NM_014421.2

Q9UBU2

Presenilin Action In Notch And Wnt Signaling Pathway (137914); Wnt Signaling Pathway (83061); Wnt Signaling Pathway (471)

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family. Protein type: Inhibitor; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q25. Cellular Component: extracellular space. Biological Process: Wnt receptor signaling pathway; multicellular organismal development

0.01 mg

160 USD

0.05 mg

310

0.1 mg

480

0.2 mg

590

0.5 mg

1150

1 mg

1710