catalog number :
MBS2010681
products type :
Recombinant Protein
products full name :
Recombinant Protectin (CD59)
products short name :
[Protectin (CD59)]
other names :
[CD59A glycoprotein; CD59A glycoprotein; CD59A glycoprotein; MACIF; MAC-IP; CD59 antigen; MAC-inhibitory protein; membrane attack complex inhibition factor; CD59a antigen; MAC-inhibitory protein; MAC-IP; Membrane attack complex inhibition factor; MACIF; Protectin]
products gene name :
[CD59]
other gene names :
[Cd59a; Cd59a; Cd59; AA987121; protectin; Cd59; MAC-IP; MACIF]
uniprot entry name :
CD59A_MOUSE
concentration :
Original Concentration: 200 ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
SDS-Page
other info1 :
Organism Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Val22~Ser96. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT,
0.01% SKL, 5% Trehalose and Proclin300.
other info2 :
Predicted isoelectric point: 5.8. Predicted Molecular Mass: 15.3kDa. Accurate Molecular Mass: 17kDa as determined by SDS-PAGE reducing conditions. USAGE: Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_001104530.1
ncbi gb acc num :
NM_001111060.2
ncbi pathways :
Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (926086); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (926012); Innate Immune System Pathway (926045); Regulation Of Complement Cascade Pathway (926095)
uniprot summary :
CD59A: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. Cellular Component: membrane; extracellular region; plasma membrane; external side of plasma membrane. Molecular Function: complement binding. Biological Process: cell activation; negative regulation of angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway; negative regulation of complement activation; negative regulation of activation of membrane attack complex