Recombinant Prostaglandin Endoperoxide Synthase 2 (PTGS2) | MyBioSource MBS2010584 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Prostaglandin Endoperoxide Synthase 2 (PTGS2)

catalog :

MBS2010584

quantity :

0.01 mg

price :

170 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2010584

products type :

Recombinant Protein

products full name :

Recombinant Prostaglandin Endoperoxide Synthase 2 (PTGS2)

products short name :

Prostaglandin Endoperoxide Synthase 2 (PTGS2)

other names :

prostaglandin G/H synthase 2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase 2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin-endoperoxide synthase 2; Cyclooxygenase-2; COX-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2; TIS10 protein

products gene name :

PTGS2

other gene names :

Ptgs2; Ptgs2; COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2; Cox-2; Cox2; Pghs-b; Tis10; COX-2; PGH synthase 2; PGHS-2

uniprot entry name :

PGH2_MOUSE

host :

E Coli

sequence length :

604

sequence :

The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-YQVIGGE VYPPTVKDTQ VEMIYPPHIP ENLQFAVGQE VFGLVPGLMM YATIWLREHN RVCDILKQEH PEWGDEQLFQ TSRLILIGET IKIVIEDYVQ HLSGYHFKLK FDPEL

purity :

> 95%

form :

Supplied as lyophilized form in PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.05% sarcosyl and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). (May be suitable for use in other assays to be determined by the end user.)

other info1 :

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Tyr240~Leu351 (Accession # Q05769) with N-terminal His-Tag. Predicted isoelectric point: 5.6

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

31981525

ncbi acc num :

NP_035328.2

ncbi gb acc num :

NM_011198.3

uniprot acc num :

Q05769

ncbi mol weight :

14.6kDa

ncbi pathways :

Arachidonic Acid Metabolism Pathway (83190); Arachidonic Acid Metabolism Pathway (926768); Arachidonic Acid Metabolism Pathway (366); Arachidonic Acid Metabolism Pathway (522975); Arachidonic Acid Metabolism Via COX (Cyclooxygenase) Pathway (522976); Chemical Carcinogenesis Pathway (673229); Chemical Carcinogenesis Pathway (673237); Eicosanoid Synthesis Pathway (198357); Leishmaniasis Pathway (144183); Leishmaniasis Pathway (144028)

uniprot summary :

COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Protein type: Oxidoreductase; EC 1.14.99.1; Lipid Metabolism - arachidonic acid. Cellular Component: neuron projection; protein complex; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; caveola; nucleus. Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; prostaglandin-endoperoxide synthase activity; protein homodimerization activity; peroxidase activity; enzyme binding; dioxygenase activity; metal ion binding; heme binding; oxidoreductase activity; lipid binding. Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; decidualization; fatty acid metabolic process; prostaglandin biosynthetic process; sensory perception of pain; negative regulation of synaptic transmission, dopaminergic; positive regulation of synaptic transmission, glutamatergic; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; regulation of blood pressure; negative regulation of smooth muscle contraction; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; angiogenesis; inflammatory response; fatty acid biosynthetic process; negative regulation of calcium ion transport; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; prostaglandin metabolic process; regulation of cell proliferation; ovulation; keratinocyte differentiation; response to cytokine stimulus; positive regulation of vasoconstriction; positive regulation of fever; brown fat cell differentiation; lipid metabolic process; response to oxidative stress; anagen; embryo implantation

size1 :

0.01 mg

price1 :

170 USD

size2 :

0.05 mg

price2 :

345

size3 :

0.1 mg

price3 :

535

more info or order :

MyBioSource product webpage