protein

Recombinant Transferrin Receptor (TFR)

MBS2010528

0.01 mg

140 USD

Recombinant Protein

Recombinant Transferrin Receptor (TFR)

[Transferrin Receptor (TFR)]

[transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; TR; tfR; tfR1; transferrin receptor]

[TFR]

[Tfrc; Tfrc; Trfr]

G3V679_RAT

E Coli

Rattus norvegicus (Rat)

>98%

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for two years. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-PAGE, WB, ELISA, IP, CoIP, ReporterAssays, Purification, Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Testing Data

Source: Prokaryotic expression. Residues: Met587~Asn756. Tags: N-terminal His-Tag. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Melanosome. Traits: Freeze-dried powder

Predicted isoelectric point: 5.2. Predicted Molecular Mass: 21.1kDa. Accurate Molecular Mass: 22kDa as determined by SDS-PAGE reducing conditions. Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

281306746

NP_073203.1

NM_022712.1

G3V679

Endocytosis Pathway (102267); Endocytosis Pathway (102181); HIF-1 Signaling Pathway (695233); Hematopoietic Cell Lineage Pathway (83470); Hematopoietic Cell Lineage Pathway (489); Iron Uptake And Transport Pathway (935913); Phagosome Pathway (153901); Phagosome Pathway (153859); Relationship Between Glutathione And NADPH Pathway (920874); Transferrin Endocytosis And Recycling Pathway (935914)

receptor for transferrin; involved in regulating stellate cell activation [RGD, Feb 2006]

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Protein type: Membrane protein, integral; Cell surface; Receptor, misc. Cellular Component: extracellular space; cell surface; mitochondrion; intracellular membrane-bound organelle; recycling endosome membrane; cell; cytoplasmic membrane-bound vesicle; integral to membrane; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane. Molecular Function: identical protein binding; transferrin receptor activity; chaperone binding; double-stranded RNA binding; Hsp70 protein binding. Biological Process: receptor-mediated endocytosis; response to inorganic substance; response to retinoic acid; cellular iron ion homeostasis; transferrin transport; osteoclast differentiation; regulation of cell proliferation; response to manganese ion; response to organic substance; response to copper ion; acute-phase response; response to hypoxia; positive regulation of bone resorption; regulation of cell growth; response to iron ion; response to nutrient; aging

0.01 mg

140 USD

0.05 mg

270

0.1 mg

420

0.2 mg

515

0.5 mg

990

1 mg

1475