Recombinant Desmoglein 1 (DSG1) | MyBioSource MBS2010418 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Desmoglein 1 (DSG1)

catalog :

MBS2010418

quantity :

0.01 mg

price :

175 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2010418

products type :

Recombinant Protein

products full name :

Recombinant Desmoglein 1 (DSG1)

products short name :

Desmoglein 1 (DSG1)

other names :

desmoglein-1 preproprotein; Desmoglein-1; desmoglein-1; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen; desmoglein 1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen

products gene name :

DSG1

other gene names :

DSG1; DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; CDHF4; DG1; DGI

uniprot entry name :

DSG1_HUMAN

host :

E Coli

sequence length :

1049

sequence :

The sequence of the target protein is listed below. E GRPSNDCLLI YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT LGPKFKKLAD ISLGKESYPD LDPSWPPQST EPVCLPQETE PVVSGHPPIS PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES YTTSDTLKPS VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI VTERVVSGAG V

purity :

> 90%

form :

Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Glu710~Val961 (Accession # Q02413) with two N-terminal Tags, His-tag and GST-tag. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction desmosome

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted Isoelectric Point: 5.4. Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4. Usage: Reconsitute in ddH2O

ncbi gi num :

119703744

ncbi acc num :

NP_001933.2

ncbi gb acc num :

NM_001942.2

uniprot acc num :

Q02413

ncbi mol weight :

58.6kDa

ncbi pathways :

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Staphylococcus Aureus Infection Pathway (172846); Staphylococcus Aureus Infection Pathway (171867)

ncbi summary :

This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

uniprot summary :

DSG1: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1); also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Protein type: Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: desmosome; internal side of plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; intercellular junction; cytosol; lateral plasma membrane. Molecular Function: toxin binding; gamma-catenin binding; calcium ion binding. Biological Process: intercellular junction assembly; cell-cell adhesion; maternal process involved in pregnancy; protein stabilization; apoptosis; calcium-dependent cell-cell adhesion; response to progesterone stimulus; homophilic cell adhesion; cell structure disassembly during apoptosis. Disease: Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse; Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-ige

size1 :

0.01 mg

price1 :

175 USD

size2 :

0.05 mg

price2 :

375

size3 :

0.1 mg

price3 :

580

more info or order :

MyBioSource product webpage