protein

Recombinant Lymphocyte Antigen 96 (LY96)

MBS2010160

0.01 mg

185 USD

Recombinant Protein

Recombinant Lymphocyte Antigen 96 (LY96)

Lymphocyte Antigen 96 (LY96)

lymphocyte antigen 96 isoform B; Lymphocyte antigen 96; lymphocyte antigen 96; ly-96; protein MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; lymphocyte antigen 96; ESOP-1; Protein MD-2

LY96

Ly96; Ly96; MD2; MD-2; ESOP-1; Esop1; Md2; Ly-96

LY96_MOUSE

E Coli

142

The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSGSEF-TESEK QQWFCNSSDA IISYSYCDHL KFPISISSEP CIRLRGTNGF VHVEFIPRGN LKYLYFNLFI SVNSIELPKR KEVLCHGHDD DYSFCRALKG ETVNTSIPFS FEGILFPKGH YRCVAEAIAG DTEEKLFCLN FTIIHRRDVN

> 95%

Supplied as lyophilized form in 10mM PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Thr16~Asn160 (Accession # Q9JHF9) with N-terminal His-Tag. Subcellular Location: Secreted, extracellular space

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted Isoelectric Point: 6.4. Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4. Reconstitution/Usage: Reconstitute in sterile ddH2O.

228008385

NP_001153183.1

NM_001159711.1

Q9JHF9

Activated TLR4 Signalling Pathway (926081); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (926067); IKK Complex Recruitment Mediated By RIP1 Pathway (926068); Immune System Pathway (926012); Innate Immune System Pathway (926045); MyD88-independent Cascade Pathway (926065); NF-kappa B Signaling Pathway (634537); Pertussis Pathway (218112); Pertussis Pathway (218099); TLR4 (Toll-like Receptor 4) Signaling Pathway (522986)

LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular region; lipopolysaccharide receptor complex. Molecular Function: protein binding; lipopolysaccharide receptor activity. Biological Process: immune system process; detection of lipopolysaccharide; lipopolysaccharide-mediated signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; response to lipopolysaccharide; pattern recognition receptor signaling pathway; inflammatory response

0.01 mg

185 USD

0.05 mg

380

0.1 mg

585