Recombinant Mannose Associated Serine Protease 2 (MASP2) | MyBioSource MBS2010123 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mannose Associated Serine Protease 2 (MASP2)

catalog :

MBS2010123

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

Sequence

product information

catalog number :

MBS2010123

products type :

Recombinant Protein

products full name :

Recombinant Mannose Associated Serine Protease 2 (MASP2)

products short name :

[Mannose Associated Serine Protease 2 (MASP2)]

other names :

[mannan-binding lectin serine protease 2 isoform 1 preproprotein; Mannan-binding lectin serine protease 2; mannan-binding lectin serine protease 2; small MBL-associated protein; MBL-associated serine protease 2; MBL-associated plasma protein of 19 kD; mannan-binding lectin serine protease 1 pseudogene 1; mannose-binding protein-associated serine protease 2; mannan-binding lectin serine peptidase 1 pseudogene 1; mannan-binding lectin serine peptidase 2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2]

products gene name :

[MASP2]

other gene names :

[MASP2; MASP2; sMAP; MAP19; MASP-2; MASP1P1; MASP-2]

uniprot entry name :

MASP2_HUMAN

host :

E Coli

purity :

> 95%

form :

PBS, pH 7.4 containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin 300.

concentration :

Original Concentration : 200 ug/mL

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

SDS-Page

image2 heading :

Testing Data (TD)

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Gly170~Thr287. Tags: N-terminal His Tag . Subcellular Location: Secreted. Traits: Freeze-dried powder. Buffer formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Predicted isoelectric point: 5.8. Predicted Molecular Mass: 14.6kDa. Accurate Molecular Mass: 16kDa as determined by SDS&PAGE reducing conditions. Reconstitution: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

21264363

ncbi acc num :

NP_006601.2

ncbi gb acc num :

NM_006610.3

uniprot acc num :

O00187

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway (833818); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Lectin Pathway Of Complement Activation (106408)

ncbi summary :

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]

uniprot summary :

MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.104; Secreted, signal peptide; Secreted; Protease. Chromosomal Location of Human Ortholog: 1p36.3-p36.2. Cellular Component: extracellular region. Molecular Function: peptidase activity; protein binding; serine-type endopeptidase activity; complement component C4b binding; calcium ion binding; calcium-dependent protein binding. Biological Process: innate immune response; proteolysis; complement activation, lectin pathway; complement activation, classical pathway; complement activation. Disease: Masp2 Deficiency

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

260

size3 :

0.1 mg

price3 :

400

size4 :

0.2 mg

price4 :

495

size5 :

0.5 mg

price5 :

955

size6 :

1 mg

price6 :

1415

more info or order :

MyBioSource product webpage