catalog number :
MBS2010071
products type :
Recombinant Protein
products full name :
Recombinant Protein S (PROS)
products short name :
Protein S (PROS)
other names :
Vitamin K-dependent protein S; Vitamin K-dependent protein S; vitamin K-dependent protein S; protein S (alpha)
products gene name :
PROS
other gene names :
Pros1; Pros1; Pros
uniprot entry name :
PROS_RAT
sequence :
The sequence of the target protein is listed below. GGYSCYCDGK KGFKLAQDQR SCEGIPVCLS LDLDKNYELL YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL LIALREGKIE VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA KEAVMNINKL GSLFKPTDGF LDTKIYFAGL PRKVESALIK PINPRLDGCI RGWNLMKQGA LGAKEIVEGK QNKHCFLTVE KGSYYPGSGI AQFSID
form :
Supplied as lyophilized form in 20mM Trism 500mM NaCI, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
storage stability :
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
tested application :
SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
other info1 :
Organism: Rattus norvegicus (Rat). Expression System: Prokaryotic expression. Residues: Gly261~Asp496 (Accession # P53813) with two N-terminal Tags, His-tag and GST-tag. Subcellular Location: Secreted
other info2 :
Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted Isoelectric Point: 6. Reconstitution: Reconstitute in ddH2O.
ncbi mol weight :
58.4kDa
ncbi pathways :
Complement And Coagulation Cascades Pathway (198461); Complement And Coagulation Cascades Pathway (83465); Complement And Coagulation Cascades Pathway (484)
ncbi summary :
component of the Protein C/Protein S anticoagulant system; human homolog interacts with factor Xa, factor Va, and phospholipids to inhibit prothrombin activation [RGD, Feb 2006]
uniprot summary :
Function: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Subcellular location: Secreted. Tissue specificity: Plasma. Post-translational modification: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains . By similarity. Sequence similarities: Contains 4 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 laminin G-like domains.