protein

Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5)

MBS2010028

0.01 mg

140 USD

Recombinant Protein

Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5)

[Defensin Alpha 5, Paneth Cell Specific (DEFa5)]

[defensin-5 preproprotein; Defensin-5; defensin-5; HD5(20-94); defensin 5; defensin, alpha 5, preproprotein; defensin, alpha 5, Paneth cell-specific; Defensin, alpha 5; HD5(20-94)]

[DEFa5]

[DEFA5; DEFA5; DEF5; HD-5; DEF5]

DEF5_HUMAN

E.coli

>90%

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

Original Concentration: 200 ug/mL

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE;Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Testing Data

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Glu20~Arg94. Tags: N-terminal His-Tag. Subcellular Location: Secreted, Exosome . Traits: Freeze-dried powder

Predicted isoelectric point: 5.9. Predicted Molecular Mass: 14.8kDa. Accurate Molecular Mass: 15kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

10337585

NP_066290.1

NM_021010.1

Q01523

Alpha-defensins Pathway (530758); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]

DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region. Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

0.01 mg

140 USD

0.05 mg

265

0.1 mg

415

0.2 mg

510

0.5 mg

990

1 mg

1465