Recombinant Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) | MyBioSource MBS2009969 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3)

catalog :

MBS2009969

quantity :

0.01 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2009969

products type :

Recombinant Protein

products full name :

Recombinant Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3)

products short name :

Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3)

other names :

aldehyde dehydrogenase family 1 member A3; Aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase family 1 member A3; RALDH-3; aldehyde dehydrogenase 6; acetaldehyde dehydrogenase 6; retinaldehyde dehydrogenase 3; aldehyde dehydrogenase 1 family, member A3; Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3

products gene name :

ALDH1A3

other gene names :

ALDH1A3; ALDH1A3; ALDH6; MCOP8; RALDH3; ALDH1A6; ALDH6; RALDH-3; RalDH3

uniprot entry name :

AL1A3_HUMAN

host :

E Coli

sequence length :

512

sequence :

The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSGSEF-RRSVEYAKK RPVGDPFDVK TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDKG LFIKPTVFSE VTDNMRIAKE EIFGPVQPIL KFKSIEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA LYAQAPFGGF KMSGNGRELG EYALAEYTEV KTVTIKLGD

purity :

> 95%

form :

Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Arg332~Asp509 (Accession # P47895) with N-terminal His-Tag. Predicted isoelectric point: 6.6. Predicted Molecular Mass: 21.2kDa

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in sterile ddH2O.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

153266822

ncbi acc num :

NP_000684.2

ncbi gb acc num :

NM_000693.2

uniprot acc num :

P47895

ncbi pathways :

Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427); Glycolysis / Gluconeogenesis Pathway (82926); Glycolysis / Gluconeogenesis Pathway (287); Histidine Metabolism Pathway (82958); Histidine Metabolism Pathway (324); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)

ncbi summary :

This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

uniprot summary :

ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family. Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.5; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: cytoplasm; cytosol. Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity. Biological Process: inner ear morphogenesis; retinal metabolic process; retinol metabolic process; embryonic eye morphogenesis; righting reflex; positive regulation of apoptosis; olfactory pit development; retinoic acid metabolic process; optic cup morphogenesis involved in camera-type eye development; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development. Disease: Microphthalmia, Isolated 8

size1 :

0.01 mg

price1 :

160 USD

size2 :

0.05 mg

price2 :

320

size3 :

0.1 mg

price3 :

495

more info or order :

MyBioSource product webpage