Recombinant Apolipoprotein C3 (APOC3) | MyBioSource MBS2009923 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Apolipoprotein C3 (APOC3)

catalog :

MBS2009923

quantity :

0.01 mg

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2009923

products type :

Recombinant Protein

products full name :

Recombinant Apolipoprotein C3 (APOC3)

products short name :

Apolipoprotein C3 (APOC3)

other names :

apolipoprotein C-III; Apolipoprotein C-III; apolipoprotein C-III; apolipoprotein C3; apolipoprotein C-III; Apolipoprotein C3

products gene name :

APOC3

other gene names :

Apoc3; Apoc3; apo-CIII; apoC-III; Apo-CIII; ApoC-III

uniprot entry name :

APOC3_MOUSE

host :

E Coli

reactivity :

Mus musculus (Mouse)

sequence length :

sequence :

The sequence of the target protein is listed below. EEVEGSLLLG SVQGYMEQAS KTVQDALSSV QESDIAVVAR GWMDNHFRFL KGYWSKFTDK FTGFWDSNPE DQPTPAIES

purity :

>90%

form :

Supplied as lyophilized form in 10mM PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Residues: Glu21~Ser99. Tags: N-terminal His-Tag. Accession: P33622. Subcellular Location: Secreted. Endotoxin Level: <1.0EU per 1ug (determined by the LAL method).

other info2 :

Predicted isoelectric point: 5.1. Predicted Molecular Mass: 10.4kDa. Accurate Molecular Mass: 21kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in sterile ddH2O.

ncbi gi num :

15421856

ncbi acc num :

NP_075603.1

ncbi gb acc num :

NM_023114.4

uniprot acc num :

P33622

ncbi pathways :

Chylomicron-mediated Lipid Transport Pathway (926692); Disease Pathway (926229); Diseases Associated With Visual Transduction Pathway (926305); HDL-mediated Lipid Transport Pathway (926693); Lipid Digestion, Mobilization, And Transport Pathway (926688); Lipoprotein Metabolism Pathway (926691); Metabolism Pathway (926669); Metabolism Of Lipids And Lipoproteins Pathway (926687); PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway (522983); PPAR Signaling Pathway (83239)

ncbi summary :

This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

uniprot summary :

APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family. Protein type: Lipid-binding; Secreted; Secreted, signal peptide. Cellular Component: extracellular space; chylomicron; cell; extracellular region. Molecular Function: lipid binding. Biological Process: response to peptide hormone stimulus; cholesterol metabolic process; triacylglycerol metabolic process; transport; lipoprotein transport; triacylglycerol catabolic process; lipoprotein metabolic process; lipid metabolic process; lipid transport; triacylglycerol mobilization; lipid catabolic process

size1 :

0.01 mg

price1 :

190 USD

size2 :

0.05 mg

price2 :

405

size3 :

0.1 mg

price3 :

625

more info or order :

MyBioSource product webpage