catalog number :
MBS2009903
products type :
Recombinant Protein
products full name :
Recombinant Plexin B1 (PLXNB1)
products short name :
[Plexin B1 (PLXNB1)]
other names :
[plexin-B1; Plexin-B1; plexin-B1; plexin 5; semaphorin receptor SEP; plexin B1; Semaphorin receptor SEP]
products gene name :
[PLXNB1]
other gene names :
[PLXNB1; PLXNB1; SEP; PLXN5; PLEXIN-B1; KIAA0407; PLXN5; SEP]
uniprot entry name :
PLXB1_HUMAN
form :
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
concentration :
Original Concentration: 200ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
Sequence Information
image2 heading :
SDS-Page
other info1 :
Source: Prokaryotic expression. Residues: Leu47~Thr173. Tags: N-terminal His-Tag. Tissue Specificity: Kidney, Brain, Lung, Liver. Subcellular Location: Membrane. Traits: Freeze-dried powder. Predicted isoelectric point: 5.5. Predicted Molecular Mass: 14.7kDa. Accurate Molecular Mass: 14kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_001123554.1
ncbi gb acc num :
NM_001130082.2
ncbi pathways :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); G Alpha (12/13) Signalling Events Pathway (106041); GPCR Downstream Signaling Pathway (119548); Sema4D In Semaphorin Signaling Pathway (119520); Sema4D Induced Cell Migration And Growth-cone Collapse Pathway (119522); Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway (119521); Semaphorin Interactions Pathway (119519)
uniprot summary :
PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; intracellular. Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity; GTPase activating protein binding; receptor activity; semaphorin receptor binding. Biological Process: positive regulation of phosphoinositide 3-kinase cascade; axon guidance; regulation of cell shape; cell migration; negative regulation of osteoblast proliferation; positive regulation of axonogenesis; negative regulation of cell adhesion; signal transduction; neurite morphogenesis; regulation of cytoskeleton organization and biogenesis