protein

Recombinant Transmembrane Protein 173 (TMEM173)

MBS2009738

0.01 mg

135 USD

Recombinant Protein

Recombinant Transmembrane Protein 173 (TMEM173)

[Transmembrane Protein 173 (TMEM173)]

[stimulator of interferon genes protein; Stimulator of interferon genes protein; stimulator of interferon genes protein; hMITA; hSTING; mediator of IRF3 activation; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; transmembrane protein 173; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173]

[TMEM173]

[TMEM173; TMEM173; ERIS; MITA; MPYS; NET23; STING; ERIS; MITA; STING; hSTING; ERIS; hMITA]

STING_HUMAN

E.coli

> 97%

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.

Original Concentration: 200ug/mL

Storage:. Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)

Sequence Information

SDS-PAGE

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Leu159~Pro373. Tags: N-terminal His Tag. Subcellular Location: Membrane

Traits: Freeze-dried powder. Predicted isoelectric point: 5.8. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

38093659

NP_938023.1

NM_198282.2

Q86WV6

Predicted Molecular Mass: 28.2kDa. Accurate Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions.

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); IRF3 Mediated Activation Of Type 1 IFN Pathway (576257); IRF3-mediated Induction Of Type I IFN Pathway (833819); Immune System Pathway (106386); Innate Immune System Pathway (106387); RIG-I-like Receptor Signaling Pathway (117292); RIG-I-like Receptor Signaling Pathway (116128); Regulation Of Innate Immune Responses To Cytosolic DNA Pathway (833823)

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; Lys-63 -linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family. Protein type: Membrane protein, multi-pass; Mitochondrial; Endoplasmic reticulum; Membrane protein, integral; Apoptosis. Chromosomal Location of Human Ortholog: 5q31.2. Cellular Component: Golgi apparatus; mitochondrial outer membrane; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; peroxisome. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; transcription factor binding; protein kinase binding. Biological Process: regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; apoptosis; positive regulation of transcription factor import into nucleus; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response; interferon-beta production. Disease: Sting-associated Vasculopathy, Infantile-onset

0.01 mg

135 USD

0.05 mg

250

0.1 mg

385

0.2 mg

470

0.5 mg

910

1 mg

1345