protein

Recombinant Lysyl Oxidase (LOX)

MBS2009694

0.01 mg

135 USD

Recombinant Protein

Recombinant Lysyl Oxidase (LOX)

[Lysyl Oxidase (LOX)]

[protein-lysine 6-oxidase isoform 1 preproprotein; Protein-lysine 6-oxidase; protein-lysine 6-oxidase; lysyl oxidase; Lysyl oxidase]

[LOX]

[LOX; LOX]

LYOX_HUMAN

E Coli

> 90%

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

Original Concentration: 200 ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Pro213~Tyr417. Tags: N-terminal His and GST Tag. Subcellular Location: Extracellular matrix. Traits: Freeze-dried powder. Predicted isoelectric point: 6.2. Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

20149540

NP_002308.2

NM_002317.5

P28300

Predicted: 53.7kDa. Accurate: 53kDa as determined by SDS-PAGE reducing conditions.

Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Formation Pathway (645288); Crosslinking Of Collagen Fibrils Pathway (730308); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262)

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. Protein type: EC 1.4.3.13; Secreted; Oxidoreductase; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q23.2. Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region; nucleus. Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity. Biological Process: response to drug; blood vessel development; elastic fiber assembly; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; response to steroid hormone stimulus; protein modification process; lung development. Disease: Cutis Laxa, Autosomal Recessive, Type Ia

0.01 mg

135 USD

0.05 mg

250

0.1 mg

385

0.2 mg

470

0.5 mg

910

1 mg

1345