catalog number :
MBS2009658
products type :
Recombinant Protein
products full name :
Recombinant Proteinase 3 (PR3)
products short name :
[Proteinase 3 (PR3)]
other names :
[myeloblastin; Myeloblastin; myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen; proteinase 3; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen]
products gene name :
[PR3]
other gene names :
[PRTN3; PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA; MBN; PR-3; PR3; NP-4]
uniprot entry name :
PRTN3_HUMAN
form :
100mM NaHCO3, 500mM NaCl, pH8.3, containing 0.01% sarcosyl, 5%Trehalose.
concentration :
Original Concentration: 200 ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
Sequence Information
image2 heading :
SDS-Page
image3 heading :
Testing Data
other info1 :
Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: His71~Leu247. Tags: N-terminal His Tag. Traits: Freeze-dried powder.
other info2 :
Predicted isoelectric point: 6.6. redicted Molecular Mass: 20.8kDa. Accurate Molecular Mass: 21/17kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_002768.3
ncbi gb acc num :
NM_002777.3
ncbi pathways :
C-MYB Transcription Factor Network Pathway (138073)
uniprot summary :
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. Protein type: Protease; Cell cycle regulation; EC 3.4.21.76. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol. Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis