Recombinant Toll Like Receptor 8 (TLR8) | MyBioSource MBS2009495 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Toll Like Receptor 8 (TLR8)

catalog :

MBS2009495

quantity :

0.01 mg

price :

130 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2009495

products type :

Recombinant Protein

products full name :

Recombinant Toll Like Receptor 8 (TLR8)

products short name :

[Toll Like Receptor 8 (TLR8)]

other names :

[toll-like receptor 8; Toll-like receptor 8; toll-like receptor 8; toll-like receptor 8]

products gene name :

[TLR8]

other gene names :

[TLR8; TLR8; CD288]

uniprot entry name :

TLR8_HUMAN

host :

E.coli

reactivity :

Human

purity :

> 95%

form :

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

concentration :

Original Concentration: 200@g/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression: Residuess: Leu844~Lys1039. Tags: N-terminal His Tag. Tissue Specificity: Membrane. Traits: Freeze-dried powder. Predicted isoelectric point: 6.1. Predicted Molecular Mass: 30.0kDa. Accurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

20302168

ncbi acc num :

NP_619542.1

ncbi gb acc num :

NM_138636.5

uniprot acc num :

Q9NR97

ncbi pathways :

Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88 Dependent Cascade Initiated On Endosome Pathway (187081); Regulation Of Toll-like Receptor Signaling Pathway (920955); TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway (187085); TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway (187082); Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway (106396); Toll Like Receptor 9 (TLR9) Cascade Pathway (106397); Toll-Like Receptors Cascades Pathway (106388); Toll-like Receptor Signaling Pathway (83076)

ncbi summary :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

uniprot summary :

TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: Xp22. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane. Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; drug binding; receptor activity. Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; microglial cell activation; positive regulation of interleukin-8 biosynthetic process; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-beta biosynthetic process; positive regulation of innate immune response; toll-like receptor signaling pathway; innate immune response; immunoglobulin mediated immune response; toll-like receptor 9 signaling pathway; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process

size1 :

0.01 mg

price1 :

130 USD

size2 :

0.05 mg

price2 :

225

size3 :

0.1 mg

price3 :

340

size4 :

0.2 mg

price4 :

415

size5 :

0.5 mg

price5 :

800

size6 :

1 mg

price6 :

1180

more info or order :

MyBioSource product webpage