Recombinant Janus Kinase 3 (JAK3) | MyBioSource MBS2009482 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Janus Kinase 3 (JAK3)

catalog :

MBS2009482

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

image 3 :

product information

catalog number :

MBS2009482

products type :

Recombinant Protein

products full name :

Recombinant Janus Kinase 3 (JAK3)

products short name :

[Janus Kinase 3 (JAK3)]

other names :

[tyrosine-protein kinase JAK3; Tyrosine-protein kinase JAK3; tyrosine-protein kinase JAK3; leukocyte Janus kinase; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3; Janus kinase 3; JAK-3; Leukocyte janus kinase]

products gene name :

[JAK3]

other gene names :

[JAK3; JAK3; JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; JAK-3; L-JAK]

uniprot entry name :

JAK3_HUMAN

host :

E. coli

purity :

>97%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.

concentration :

Original Concentration: 200ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB)

app notes :

(May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence

image2 heading :

SDS-PAGE

image3 heading :

Gene Sequencing (Extract)

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Trp716~Asp967. Tags: N-terminal His Tag. Subcellular Location: Membrane, Cytoplasm, Endoplasmic reticulum lumen. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 8.5. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

47157315

ncbi acc num :

NP_000206.2

ncbi gb acc num :

NM_000215.3

uniprot acc num :

P52333

ncbi mol weight :

Predicted Molecular Mass: 32.3kDa. Accurate Molecular Mass: 32kDa as determined by SDS-PAGE reducing conditions.

ncbi pathways :

CD40/CD40L Signaling Pathway (138061); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine Signaling In Immune System Pathway (366171); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020)

ncbi summary :

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

uniprot summary :

JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described. Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; JakA family. Chromosomal Location of Human Ortholog: 19p13.1. Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; endomembrane system; cytosol. Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; hormone receptor binding. Biological Process: cell migration; negative regulation of interleukin-12 production; peptidyl-tyrosine phosphorylation; negative regulation of interleukin-10 production; negative regulation of T-helper 1 cell differentiation; negative regulation of FasL biosynthetic process; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; regulation of apoptosis; negative regulation of dendritic cell cytokine production; tyrosine phosphorylation of STAT protein; B cell differentiation; innate immune response; erythrocyte differentiation; T cell homeostasis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; inflammatory response; negative regulation of T cell activation; transmembrane receptor protein tyrosine kinase signaling pathway; STAT protein nuclear translocation. Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-negative

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

270

size3 :

0.1 mg

price3 :

420

size4 :

0.2 mg

price4 :

515

size5 :

0.5 mg

price5 :

995

size6 :

1 mg

price6 :

1480

more info or order :

MyBioSource product webpage