catalog number :
MBS2009407
products type :
Recombinant Protein
products full name :
Recombinant Laminin Gamma 3 (LAMC3)
products short name :
[Laminin Gamma 3 (LAMC3)]
other names :
[laminin subunit gamma-3; Laminin subunit gamma-3; laminin subunit gamma-3; laminin-12 subunit gamma; laminin-14 subunit gamma; laminin-15 subunit gamma; laminin gamma 3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma]
products gene name :
[LAMC3]
other gene names :
[Lamc3; Lamc3; AI562206; AW240805]
uniprot entry name :
LAMC3_MOUSE
form :
Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
concentration :
Original Concentration: 200 Ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control, Immunogen, SDS-PAGE, WB.
(May be suitable for use in other assays to be determined by the end user.)
image1 heading :
SDS-Page
other info1 :
Organism Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Lys1250~Lys1418. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose
other info2 :
Predicted isoelectric point: 9.9. Predicted Molecular Mass: 19.6kDa. Accurate Molecular Mass: 21kDa as determined by SDS-PAGE reducing conditions. USAGE: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
products description :
About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.
ncbi acc num :
NP_035966.2
ncbi gb acc num :
NM_011836.3
ncbi pathways :
Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (927061); Focal Adhesion Pathway (198353); Focal Adhesion Pathway (83264); Focal Adhesion Pathway (478); Laminin Interactions Pathway (927070); Non-integrin Membrane-ECM Interactions Pathway (927071)
uniprot summary :
LAMC3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMC3 are the cause of cortical malformations occipital (OCCM). OCCM is a disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes. Protein type: Extracellular matrix; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Cellular Component: proteinaceous extracellular matrix; extracellular region; basement membrane. Biological Process: cellular morphogenesis during differentiation; visual perception; retina development in camera-type eye; cell adhesion; astrocyte development