Recombinant Transferrin Receptor 2 (TFR2) | MyBioSource MBS2009385 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Recombinant Transferrin Receptor 2 (TFR2)

catalog :

MBS2009385

quantity :

0.01 mg

price :

235 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2009385

products type :

Recombinant Protein

products full name :

Recombinant Transferrin Receptor 2 (TFR2)

products short name :

Transferrin Receptor 2 (TFR2)

other names :

transferrin receptor protein 2 isoform 2; Transferrin receptor protein 2; transferrin receptor protein 2; transferrin receptor 2; N/A

products gene name :

TFR2

other gene names :

TFR2; TFR2; HFE3; TFRC2; TfR2

uniprot entry name :

TFR2_HUMAN

host :

E Coli

sequence length :

630

sequence :

The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below. MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-YENLHKV LQGRLPAVAQ AVAQLAGQLL IRLSHDRLLP LDFGRYGDVV LRHIGNLNEF SGDLKARGLT LQWVYSARGD YIRAAEKLRQ EIYSSEERDE RLT

purity :

> 95%

form :

Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Tyr604~Thr703 (Accession # Q9UP52) with two N-terminal Tags, His-tag and GST-tag. Subcellular Location: Cell Membrane; Single-pass type II membrane protein. Predicted isoelectric point: 6.4

other info2 :

Endotoxin Level: Reconstitute in sterile PBS, pH7.2-pH7.4.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

332309171

ncbi acc num :

NP_001193784.1

ncbi gb acc num :

NM_001206855.1

uniprot acc num :

Q9UP52

ncbi mol weight :

43.4kDa

ncbi pathways :

Iron Metabolism In Placenta Pathway 672461

ncbi summary :

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

uniprot summary :

Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Subunit structure: Homodimer. Subcellular location: Cell membrane; Single-pass type II membrane protein. Isoform Beta: Cytoplasm . Probable. Note: Lacks the transmembrane domain. Probably intracellular. Tissue specificity: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly. Involvement in disease: Hemochromatosis 3 (HFE3) [MIM:604250]: A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.9 Ref.10 Ref.12. Miscellaneous: The variant Lys-172 found in hereditary hemochromatosis type III affects the putative initiation codon of the beta isoform thuspreventing its translation. Sequence similarities: Belongs to the peptidase M28 family. M28B subfamily. Sequence caution: The sequence BAA91153.1 differs from that shown. Reason: Erroneous initiation.

size :

0.01 mg

price :

235 USD

more info or order :

MyBioSource product webpage