protein

Recombinant Transferrin Receptor 2 (TFR2)

MBS2009338

0.01 mg

160 USD

Recombinant Protein

Recombinant Transferrin Receptor 2 (TFR2)

Transferrin Receptor 2 (TFR2)

transferrin receptor protein 2 isoform 2; Transferrin receptor protein 2; transferrin receptor protein 2; transferrin receptor 2

TFR2

TFR2; TFR2; HFE3; TFRC2; TfR2

TFR2_HUMAN

E Coli

630

The sequence of the target protein is listed below. LHWVDEAGKV GEQLPLEDPD VYCPYSAIGN VTGELVYAHY GRPEDLQDLR ARGVDPVGRL LLVRVGVISF AQKVTNAQDF GAQGVLIYPE PADFSQDPPK PSLSSQQAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVASSG LPSIPAQPIS ADIASRLLRK LKGPVAPQEW QGSLLGSPYH LGPGPRLRLV VNNHR

>90%

Supplied as lyophilized form in PBS, pH 7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Leu211~Arg405 (Accession # Q9UP52) with N-terminal His-Tag. Subcellular Location: Cell membrane; Single-pass type II membrane protein

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted Isoelectric Point: 6.3. Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4. Accurate Molecular Mass: 26kDa as determined by SDS-PAGE reducing conditions.

332309171

NP_001193784.1

NM_001206855.1

Q9UP52

22.6kDa

Iron Metabolism In Placenta Pathway (672461)

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: integral to plasma membrane; cytoplasm. Molecular Function: transferrin receptor activity. Biological Process: receptor-mediated endocytosis; cellular iron ion homeostasis; iron ion transport. Disease: Hemochromatosis, Type 3

0.01 mg

160 USD

0.05 mg

320

0.1 mg

495