Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) | MyBioSource MBS2009140 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R)

catalog :

MBS2009140

quantity :

0.01 mg

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2009140

products type :

Recombinant Protein

products full name :

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R)

products short name :

Insulin Like Growth Factor 2 Receptor (IGF2R)

other names :

cation-independent mannose-6-phosphate receptor; Cation-independent mannose-6-phosphate receptor; cation-independent mannose-6-phosphate receptor; M6PR; MPR 300; IGF-II/CI-MPR; IGF-II receptor; M6P/IGF2 receptor; CI Man-6-P receptor; cation-independent MPR; 300 kDa mannose 6-phosphate receptor; insulin-like growth factor II receptor; cation-independent mannose 6-phosphate receptor; mannose-6-phosphate receptor, cation independent; insulin-like growth factor 2 receptor; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor

products gene name :

IGF2R

other gene names :

Igf2r; Igf2r; CD222; CI-MPR; Mpr300; AI661837; M6P/IGF2R; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R

uniprot entry name :

MPRI_MOUSE

host :

E Coli

reactivity :

Mus musculus (Mouse)

sequence length :

2483

sequence :

The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-VQI SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY YLRVCGKLSS DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG LLKMNYTGGD TCHKVYQRST TIYFYCDRTT QKPVFLKETS DCSYMFEWRT QYACPPFNVT ECSVQ

purity :

> 95%

form :

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Expression System: Prokaryotic expression. Residues: Val1148~Gln1365 (Accession # Q07113) with two N-terminal Tags, His-tag and T7-tag. Subcellular Location: Lysosome membrane; Single-pass type I membrane protein.

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted Isoelectric Point: 7.5. Reconstitution: Reconstitute in ddH2O.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

133778978

ncbi acc num :

NP_034645.2

ncbi gb acc num :

NM_010515.2

uniprot acc num :

Q07113

ncbi mol weight :

28.3kDa

ncbi pathways :

Clathrin Derived Vesicle Budding Pathway (927296); Golgi Associated Vesicle Biogenesis Pathway (927297); Lysosome Pathway (99272); Lysosome Pathway (96865); Membrane Trafficking Pathway (927292); PI3K/Akt/mTOR Signaling Pathway (522982); Trans-Golgi Network Vesicle Budding Pathway (927295)

uniprot summary :

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Protein type: Membrane protein, integral; Receptor, misc.; Vesicle. Cellular Component: extracellular space; focal adhesion; clathrin coat; cell surface; lysosome; integral to membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; endocytic vesicle; late endosome; cytoplasm; plasma membrane; nucleus; endosome. Molecular Function: G-protein coupled receptor activity; mannose binding; identical protein binding; insulin-like growth factor binding; enzyme binding; retinoic acid binding; transporter activity; G-protein alpha-subunit binding; phosphoprotein binding; glycoprotein binding; insulin-like growth factor II binding. Biological Process: regulation of apoptosis; G-protein coupled receptor protein signaling pathway; response to retinoic acid; positive regulation of apoptosis; transport; liver development

size1 :

0.01 mg

price1 :

190 USD

size2 :

0.05 mg

price2 :

400

size3 :

0.1 mg

price3 :

620

more info or order :

MyBioSource product webpage