Recombinant Neuregulin 2 (NRG2) | MyBioSource MBS2009107 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Neuregulin 2 (NRG2)

catalog :

MBS2009107

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2009107

products type :

Recombinant Protein

products full name :

Recombinant Neuregulin 2 (NRG2)

products short name :

[Neuregulin 2 (NRG2)]

other names :

[pro-neuregulin-2, membrane-bound isoform isoform 7; Pro-neuregulin-2, membrane-bound isoform; pro-neuregulin-2, membrane-bound isoform; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; neuregulin 2; Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases]

products gene name :

[NRG2]

other gene names :

[NRG2; NRG2; DON1; HRG2; NTAK; NTAK; Pro-NRG2; NRG-2; DON-1; NTAK]

uniprot entry name :

NRG2_HUMAN

host :

E.coli

purity :

> 97%

form :

PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

concentration :

Original Concentration: 200ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)

app notes :

(May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence

image2 heading :

SDS-PAGE

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Phe101~Phe211. Tags: N-terminal His Tag. Subcellular Location: Membrane, Secreted

other info2 :

Traits: Freeze-dried powder. Predicted isoelectric point: 9.1. Usage: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

296531452

ncbi acc num :

NP_001171864.1

ncbi gb acc num :

NM_001184935.1

uniprot acc num :

O14511

ncbi mol weight :

Predicted Molecular Mass: 13.3kDa. Accurate Molecular Mass: 14kDa as determined by SDS-PAGE reducing conditions.

ncbi pathways :

Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downregulation Of ERBB2:ERBB3 Signaling Pathway (530740); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signal Transduction Pathway (106385); Downstream Signaling Of Activated FGFR Pathway (160957); ErbB Receptor Signaling Network Pathway (138016)

ncbi summary :

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

uniprot summary :

NRG2: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Belongs to the neuregulin family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase. Chromosomal Location of Human Ortholog: 5q31.2. Cellular Component: extracellular space; integral to membrane; extracellular region; plasma membrane. Molecular Function: growth factor activity; receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response; signal transduction

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

270

size3 :

0.1 mg

price3 :

420

size4 :

0.2 mg

price4 :

515

size5 :

0.5 mg

price5 :

995

size6 :

1 mg

price6 :

1480

more info or order :

MyBioSource product webpage