Recombinant Ficolin 3 (FCN3) | MyBioSource MBS2009080 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Ficolin 3 (FCN3)

catalog :

MBS2009080

quantity :

0.01 mg

price :

115 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2009080

products type :

Recombinant Protein

products full name :

Recombinant Ficolin 3 (FCN3)

products short name :

[Ficolin 3 (FCN3)]

other names :

[ficolin-3 isoform 1; Ficolin-3; ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); ficolin (collagen/fibrinogen domain containing) 3; Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen]

products gene name :

[FCN3]

other gene names :

[FCN3; FCN3; FCNH; HAKA1; FCNH; HAKA1]

uniprot entry name :

FCN3_HUMAN

host :

E. coli

reactivity :

Homo sapiens (Human)

purity :

>97%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300

concentration :

200ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression. Residues: Glu34~Met297. Tags: N-terminal His-Tag. Tissue Specificity: Liver, Lung, Heart, Brain, Kidney. Subcellular Location: Secreted. Traits: Freeze-dried powder. Predicted isoelectric point: 6.3. Predicted Molecular Mass: 30.2kDa. Accurate Molecular Mass: 31kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

27754776

ncbi acc num :

NP_003656.2

ncbi gb acc num :

NM_003665.2

uniprot acc num :

O75636

ncbi pathways :

Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway (833818); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Lectin Pathway Of Complement Activation (106408)

ncbi summary :

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: collagen; extracellular region. Molecular Function: protein binding; carbohydrate binding; antigen binding. Biological Process: negative regulation of virion penetration into host cell; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; defense response to virus; complement activation. Disease: Immunodeficiency Due To Ficolin 3 Deficiency

size1 :

0.01 mg

price1 :

115 USD

size2 :

0.05 mg

price2 :

205

size3 :

0.1 mg

price3 :

295

size4 :

0.2 mg

price4 :

370

size5 :

0.5 mg

price5 :

710

size6 :

1 mg

price6 :

1050

more info or order :

MyBioSource product webpage