antibody

Polyclonal Antibody to Interleukin 7 Receptor (IL7R)

MBS2007286

0.01 mg

110 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

Antibody

Polyclonal Antibody to Interleukin 7 Receptor (IL7R)

[Interleukin 7 Receptor (IL7R)]

[interleukin-7 receptor subunit alpha isoform 1; Interleukin-7 receptor subunit alpha; interleukin-7 receptor subunit alpha; interleukin 7 receptor; CD_antigen: CD127]

[IL7R]

[Il7r; Il7r; CD127; IL-7Ralpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA]

Polyclonal

Rabbit

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.

1 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB; IHC; ICC; IP.

Western blotting: 0.5-2 ug/uL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.

Western Blot (WB)

Immunohistochemistry (IHC)

Organism Species: Mus musculus. Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant IL7R (Val48~Phe217) expressed in E.coli

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2060452

45269152

NP_032398.3

NM_008372.4

P16872

Cytokine Signaling In Immune System Pathway (1110778); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); FoxO Signaling Pathway (921412); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); IL-7 Signaling Pathway (198324); Immune System Pathway (1110668); Interleukin-7 Signaling Pathway (1110794); Jak-STAT Signaling Pathway (83274)

Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]

IL7R: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Defects in IL7R are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell- positive/NK-cell-positive (T(-)B(+)NK(+) SCID). A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Genetic variations in IL7R are a cause of susceptibility to multiple sclerosis type 3 (MS3). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. Belongs to the type I cytokine receptor family. Type 4 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 15 A1 15 4.16 cM. Cellular Component: external side of plasma membrane; integral component of membrane; membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity. Biological Process: B cell proliferation; cell growth; cell morphogenesis; homeostasis of number of cells; immunoglobulin production; lymph node development; negative regulation of T cell mediated cytotoxicity; positive regulation of gene expression; positive regulation of T cell differentiation in thymus; regulation of cell size; T cell differentiation

0.01 mg

110 USD

0.02 mg

125

0.05 mg

175

0.1 mg

225

0.2 mg

330

1 mg

785