Biotin-Linked Antibody to Corticotropin Releasing Hormone (CRH) | MyBioSource MBS2007137 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Biotin-Linked Antibody to Corticotropin Releasing Hormone (CRH)

catalog :

MBS2007137

quantity :

0.1 mg

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2007137

products type :

Antibody

products full name :

Biotin-Linked Antibody to Corticotropin Releasing Hormone (CRH)

products short name :

[Corticotropin Releasing Hormone (CRH)]

other names :

[corticotropin releasing hormone; Corticoliberin; corticoliberin; corticotropin-releasing factor; corticotropin releasing hormone; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone]

products gene name :

[CRH]

other gene names :

[CRH; CRH; CRF; CRF]

uniprot entry name :

CRF_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mus musculus (Mouse)

sequence length :

196

specificity :

The antibody is a rabbit polyclonal antibody raised against CRH conjugated to biotin. It has been selected for its ability to recognize CRH in immunohistochemical staining andwestern blotting.

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.3mg/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB, IHC, ICC.

app notes :

Western blotting: 0.5-2) Ug/mL;1:150-600. Immunohistochemistry: 5-20)Ug/mL;1:15-60. Immunocytochemistry: 5-20)Ug/mL;1:15-60. Optimal working dilutions must be determined by end user.

other info1 :

. Source: Antibody labeling. Label: Biotin

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2006955

products categories :

Biotin Antibody

ncbi gi num :

119607303

ncbi acc num :

EAW86897.1

uniprot acc num :

P06850

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Class B/2 (Secretin Family Receptors) Pathway (106378); Corticotropin-releasing Hormone Pathway (920957); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Long-term Depression Pathway (83086); Long-term Depression Pathway (497); Myometrial Relaxation And Contraction Pathways (198759)

ncbi summary :

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

uniprot summary :

CRH: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8q13. Cellular Component: extracellular space; cytoplasm; extracellular region; perikaryon. Molecular Function: corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; protein binding; hormone activity; corticotropin-releasing hormone receptor 2 binding; adrenocorticotropin-releasing hormone activity; receptor binding. Biological Process: synaptic transmission, dopaminergic; diterpenoid metabolic process; negative regulation of circadian sleep/wake cycle, REM sleep; positive regulation of cortisol secretion; hypothalamus development; induction of apoptosis by hormones; response to pain; female pregnancy; signal transduction; positive regulation of adrenocorticotropic hormone secretion; synaptic transmission; negative regulation of luteinizing hormone secretion; learning and/or memory; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; feeding behavior; negative regulation of blood pressure; parturition; inflammatory response; response to electrical stimulus; associative learning; response to corticosterone stimulus; response to drug; adrenal gland development; response to ether; response to ethanol; long-term memory; response to estrogen stimulus; ion homeostasis; regulation of serotonin secretion; negative regulation of epinephrine secretion; positive regulation of protein amino acid phosphorylation; glucocorticoid biosynthetic process; lung development. Disease: Acth Deficiency, Isolated

size1 :

0.1 mg

price1 :

230 USD

size2 :

0.2 mg

price2 :

345

size3 :

1 mg

price3 :

815

more info or order :

MyBioSource product webpage