Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | MyBioSource MBS2007085 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS)

catalog :

MBS2007085

quantity :

0.01 mg

price :

130 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2007085

products type :

Antibody

products full name :

Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS)

products short name :

Inducible T-Cell Co Stimulator (ICOS)

other names :

inducible T-cell co-stimulator; Inducible T-cell costimulator; inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator; Activation-inducible lymphocyte immunomediatory molecule

products gene name :

ICOS

other gene names :

ICOS; ICOS; AILIM; CD278; CVID1; AILIM

uniprot entry name :

ICOS_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

The antibody is a rabbit polyclonal antibody raised against ICOS. It has been selected for its ability to recognize ICOS in immunohistochemical staining andwestern blotting.

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.

app notes :

Western blotting: 0.5-2ug/ml. Immunocytochemistry in formalin fixed cells: 5-20ug/ml. Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml. Immunohistochemistry in paraffin section: 5-20ug/ml. Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml. Optimal working dilutions must be determined by end user.

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid

other info2 :

Immunogen: Recombinant ICOS (Asn35~Ile131) expressed in E.coli.

ncbi gi num :

9968296

ncbi acc num :

CAC06612.1

uniprot acc num :

Q9Y6W8

ncbi pathways :

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537); T Cell Receptor Signaling Pathway (83080)

ncbi summary :

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

uniprot summary :

ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q33. Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane. Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1

size1 :

0.01 mg

price1 :

130 USD

size2 :

0.05 mg

price2 :

225

size3 :

0.1 mg

price3 :

290

more info or order :

MyBioSource product webpage