catalog number :
MBS2006881
products full name :
Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1)
products short name :
[Transforming Growth Factor Beta 1 (TGFb1)]
other names :
[Transforming growth factor beta-1; Transforming growth factor beta-1; transforming growth factor beta-1; LOW QUALITY PROTEIN: transforming growth factor beta-1; transforming growth factor beta 1]
products gene name :
[TGFb1]
other gene names :
[TGFB1; TGFB1; TGFB4; TGF-beta4; TGF-beta-1; LAP]
sequence :
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF- D LDTDYCFGPG TDEKNCCVRP LYIDFRKDLQ WKWIHEPKGY MANFCMGPCP YIWSADTQYT KVLALYNQHN PGASAAPCCV PQTLDPLPII YYVGRNVRVE QLSNMVVRAC KCS
specificity :
The antibody is a rabbit polyclonal antibody raised against TGFb1. It has been selected for its ability to recognize TGFb1 in immunohistochemical staining andwestern blotting.
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01 M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
WB; IHC; ICC; IP.
app notes :
Store: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
image1 heading :
Western Blot (WB)
other info1 :
Source: Polyclonal antibody preparation. Traits: Liquid
other info2 :
Immunogen: Recombinant TGFb1 (Asp260-Ser373 (Accession # P09531)} expressed in E.eol;. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2038230
ncbi mol weight :
42,635 Da
ncbi pathways :
AGE-RAGE Signaling Pathway In Diabetic Complications (1319972); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Cell Cycle Pathway (83960); Cell Cycle Pathway (463); Cytokine-cytokine Receptor Interaction Pathway (119307); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (102290); Endocytosis Pathway (102181); FoxO Signaling Pathway (921354); Intestinal Immune Network For IgA Production Pathway (128762)
uniprot summary :
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus ().