Polyclonal Antibody to Interferon Alpha/Beta Receptor 1 (IFNa/bR1) | MyBioSource MBS2006874 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Interferon Alpha/Beta Receptor 1 (IFNa/bR1)

catalog :

MBS2006874

quantity :

0.01 mg

price :

135 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2006874

products type :

Antibody

products full name :

Polyclonal Antibody to Interferon Alpha/Beta Receptor 1 (IFNa/bR1)

products short name :

Interferon Alpha/Beta Receptor 1 (IFNa/bR1)

other names :

interferon alpha/beta receptor 1; Interferon alpha/beta receptor 1; interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain; interferon (alpha, beta and omega) receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1

products gene name :

IFNa/bR1

other gene names :

IFNAR1; IFNAR1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC; IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1

uniprot entry name :

INAR1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

557

sequence :

The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-RAEEGNS TSSWNEVDPF IPFYTAHMSP PEVRLEAEDK AILVHISPPG QDGNMWALEK PSFSYTIRIW QKSSSDKKTI NSTYYVEKIP ELLPETTYCL EVKAIHPSLK KHSNYSTVQC ISTTVANKMP VPGNLQVDAQ GKSYVLKWDY IASADVLFRA QWLPGYSKSS SGSRSDKWKP IPTCANVQTT HCVFSQDTVY TGTFFLHVQA SEGNHTSFWS EEKFIDSQKH ILPPPPVITV T

specificity :

The antibody is a rabbit polyclonal antibody raised against IFNa/bR1. It has been selected for its ability to recognize IFNa/bR1 in immunohistochemical staining and western blotting.

purity :

Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

200ug/ml

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

app notes :

Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200. Optimal working dilutions must be determined by end user.

ncbi gi num :

46488932

ncbi acc num :

NP_000620.2

ncbi gb acc num :

NM_000629.2

uniprot acc num :

P17181

ncbi mol weight :

63,525 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Hepatitis B Pathway (694606); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Immune System Pathway (106386)

ncbi summary :

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

uniprot summary :

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane. Molecular Function: protein binding; interferon receptor activity; interferon-alpha/beta receptor activity. Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus

size1 :

0.01 mg

price1 :

135 USD

size2 :

0.05 mg

price2 :

230

size3 :

0.1 mg

price3 :

310

more info or order :

MyBioSource product webpage