product summary
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company name :
MyBioSource
product type :
antibody
product name :
Polyclonal Antibody to A Disintegrin And Metalloprotease 6 (ADAM6)
catalog :
MBS2006770
quantity :
0.05 mg
price :
340 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2006770
products type :
Antibody
products full name :
Polyclonal Antibody to A Disintegrin And Metalloprotease 6 (ADAM6)
products short name :
A Disintegrin And Metalloprotease 6 (ADAM6)
other names :
A disintegrin and metalloproteinase with thrombospondin motifs 6 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 6; A disintegrin and metalloproteinase with thrombospondin motifs 6; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6; ADAM metallopeptidase with thrombospondin type 1 motif, 6
products gene name :
ADAM6
other gene names :
ADAMTS6; ADAMTS6; ADAM-TS6; ADAMTS-6; ADAM-TS 6; ADAM-TS 6; ADAM-TS6; ADAMTS-6
uniprot entry name :
ATS6_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Rat
sequence length :
1117
sequence :
The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF-FC GNFKIDIGEQ CDCGSHKACY ADPCCGSNCK LTAGSICDKE LCCANCTYSP SGTLCRPIQN ICDLPEYCSG NNIFCPADTY LQDGTPCSEE GYCYKGNCTD RSVQCKEIFG VNAKGANIKC YDINKQRFRF GHCTRAQESL MFNACSDHDK LCGRLQCTNV TNLPFLQEHV SFHQSVISGF TCFGLDEHRG TETTDAGLVK HGTPCSQTNF CDRGACNGSL SRLDYDCTPE KCNFRGVCNN HRHC
specificity :
The antibody is a rabbit polyclonal antibody raised against ADAM6. It has been selected for its ability to recognize ADAM6 in immunohistochemical staining andwestern blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
concentration :
200ug/ml
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
app notes :
Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200
other info1 :
Immunogen: Recombinant ADAM6 (Phe419~Cys664) expressed in E.coli.
other info2 :
Quality Control: Content: The quality control contains recombinant Thyroglobulin (Ser2083~Ala2333) disposed in loading buffer. Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate. 5uL per well when used in enhanced chemilumescent (ECL). Note: The quality control is specifically manufactured as the positive control.Not used for other purposes. Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
ncbi gi num :
64276808
ncbi acc num :
NP_922932.2
ncbi gb acc num :
NM_197941.2
uniprot acc num :
Q9UKP5
ncbi mol weight :
125,273 Da
uniprot summary :
Cofactor: Binds 1 zinc ion per subunit . By similarity. Subcellular location: Secreted extracellular space extracellular matrix . By similarity. Tissue specificity: Expressed at low levels in placenta and barely detectable in a number of other tissues. Induction: Isoform 1 and isoform 2 expressions are up-regulated by TNF in retinal pigment epithelial cells. Ref.2 Ref.6. Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. Post-translational modification: The precursor is cleaved by a furin endopeptidase . By similarity.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion . By similarity. Sequence similarities: Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.Contains 1 PLAC domain.Contains 5 TSP type-1 domains.
size :
0.05 mg
price :
340 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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