Polyclonal Antibody to Transferrin Receptor (TFR) | MyBioSource MBS2006760 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Transferrin Receptor (TFR)

catalog :

MBS2006760

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Lane1: Human Hela Cells; Lane2: Human Jurkat Cells.

image 2 :

Western Blot: Sample: Recombinant TFR, Mouse.

image 3 :

DAB staining on fromalin fixed paraffin-embedded Kidney tissue)

product information

catalog number :

MBS2006760

products type :

Antibody

products full name :

Polyclonal Antibody to Transferrin Receptor (TFR)

products short name :

[Transferrin Receptor (TFR)]

other names :

[transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor; CD_antigen: CD71]

products gene name :

[TFR]

other gene names :

[Tfrc; Tfrc; TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik; Trfr; TR; TfR; TfR1; Trfr]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

The antibody is a Rabbit polyclonal antibody raised against TFR. It has been selected for its ability to recognize TFR in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-5µg/mL. Immunocytochemistry in formalin fixed cells: 5-20µg/mL. Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL. Immunohistochemistry in paraffin section: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TFR (Arg572~Trp757) expressed in E.coli.

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2052125

ncbi gi num :

11596855

ncbi acc num :

NP_035768.1

ncbi gb acc num :

NM_011638.4

uniprot acc num :

Q62351

ncbi mol weight :

85,731 Da

ncbi pathways :

Clathrin Derived Vesicle Budding Pathway (366623); Endocytosis Pathway (102286); Endocytosis Pathway (102181); Golgi Associated Vesicle Biogenesis Pathway (366624); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Membrane Trafficking Pathway (366619); Phagosome Pathway (153914); Phagosome Pathway (153859); Trans-Golgi Network Vesicle Budding Pathway (366622)

ncbi summary :

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]

uniprot summary :

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 16 B3 16 23.06 cM. Cellular Component: basolateral plasma membrane; blood microparticle; cell surface; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; early endosome; endosome; endosome membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; HFE-transferrin receptor complex; integral component of membrane; integral component of plasma membrane; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane. Molecular Function: chaperone binding; double-stranded RNA binding; Hsp70 protein binding; identical protein binding; iron ion transmembrane transporter activity; protein binding; protein homodimerization activity; RNA binding; transferrin receptor activity; transferrin transmembrane transporter activity. Biological Process: cellular iron ion homeostasis; cellular response to extracellular stimulus; cellular response to iron ion; endocytosis; osteoclast differentiation; positive regulation of B cell proliferation; positive regulation of bone resorption; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; receptor-mediated endocytosis; transferrin transport

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

125

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

330

size6 :

1 mg

price6 :

785

more info or order :

MyBioSource product webpage