Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3) | MyBioSource MBS2006635 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)

catalog :

MBS2006635

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant protein.

image 2 :

DAB staining on IHC-P; Samples: Human Pancreas Tissue)

product information

catalog number :

MBS2006635

products type :

Antibody

products full name :

Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)

products short name :

[Defensin Alpha 3, Neutrophil Specific (DEFa3)]

other names :

[neutrophil defensin 3 preproprotein; Neutrophil defensin 3; neutrophil defensin 3; defensin alpha 3; Defensin, alpha 3; HNP-3; HP-3; HP3]

products gene name :

[DEFa3]

other gene names :

[DEFA3; DEFA3; HP3; DEF3; HNP3; HP-3; HNP-3; DEF3; HP-3; HP3; HP-2; HP2]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

sequence :

Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF-E PLQARADEVA AAPEQIAADI PEVVVSLAWD ESLAPKHPGS RKNMDCYCRI PACIAGERRY GTCIYQGRLW AFCC

specificity :

The antibody is a rabbit polyclonal antibody raised against DEFa3. It has been selected for its ability to recognize DEFa3 in immunohistochemical staining andwestern blotting.

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid

other info2 :

Immunogen: Recombinant DEFa3 (Pro21~Cys94) expressed in E.coli. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2073998

ncbi gi num :

4885179

ncbi acc num :

NP_005208.1

ncbi gb acc num :

NM_005217.3

uniprot acc num :

P59666

ncbi mol weight :

10,245 Da

ncbi pathways :

Alpha-defensins Pathway (1269266); Antimicrobial Peptides Pathway (1457777); Defensins Pathway (1269265); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]

uniprot summary :

defensin, alpha 3: Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular region; extracellular space; Golgi lumen. Molecular Function: protein homodimerization activity. Biological Process: antibacterial humoral response; antimicrobial humoral response; defense response to fungus; defense response to Gram-positive bacterium; defense response to virus; innate immune response in mucosa; intracellular estrogen receptor signaling pathway; killing of cells of other organism

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

340

size6 :

1 mg

price6 :

800

more info or order :

MyBioSource product webpage