catalog number :
MBS2005660
products full name :
Polyclonal Antibody to Uncoupling Protein 1, Mitochondrial (UCP1)
products short name :
[Uncoupling Protein 1, Mitochondrial (UCP1)]
other names :
[mitochondrial brown fat uncoupling protein 1; Mitochondrial brown fat uncoupling protein 1; mitochondrial brown fat uncoupling protein 1; uncoupling protein 1 (mitochondrial, proton carrier); Solute carrier family 25 member 7]
products gene name :
[UCP1]
other gene names :
[Ucp1; Ucp1; Ucp; Slc25a7; AI385626; UCP 1Curated]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP)
app notes :
Western blotting: 0.5-2ug/mL; . Immunohistochemistry: 5-20ug/mL;. Immunocytochemistry: 5-20ug/mL;. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant UCP1 (Pro179~Leu296) expressed in E.coli
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2076866
ncbi acc num :
NP_033489.1
ncbi gb acc num :
NM_009463.3
ncbi pathways :
Adipogenesis Genes Pathway (198299); Electron Transport Chain Pathway (198400); Huntington's Disease Pathway (83297); Huntington's Disease Pathway (512); Metabolism Pathway (1367614); Mitochondrial Uncoupling Proteins Pathway (1367785); PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway (522983); PPAR Signaling Pathway (83239); PPAR Signaling Pathway (450); PPAR Signaling Pathway (694605)
uniprot summary :
UCP1: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial. Chromosomal Location of Human Ortholog: 8 C2 8 39.65 cM. Cellular Component: integral component of membrane; membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrial membrane; mitochondrion. Molecular Function: GDP binding; GTP binding; oxidative phosphorylation uncoupler activity; protein binding; purine ribonucleotide binding; transmembrane transporter activity. Biological Process: brown fat cell differentiation; cellular response to hormone stimulus; diet induced thermogenesis; ion transport; mitochondrial transport; proton transport; regulation of transcription from RNA polymerase II promoter; response to cold; response to nutrient levels; response to temperature stimulus; transport