antibody

Biotin-Linked Antibody to Arginase II (Arg2)

MBS2005375

0.1 mg

250 USD

polyclonal

rabbit

biotin

human, mouse

western blot, immunohistochemistry, immunocytochemistry

Antibody

Biotin-Linked Antibody to Arginase II (Arg2)

[Arginase II (Arg2)]

[arginase II; Arginase-2, mitochondrial; arginase-2, mitochondrial; kidney arginase; type II arginase; arginase, type II; nonhepatic arginase; kidney-type arginase; non-hepatic arginase; L-arginine ureahydrolase; L-arginine amidinohydrolase; arginase 2; Kidney-type arginase; Non-hepatic arginase; Type II arginase]

[Arg2]

[ARG2; ARG2]

ARGI2_HUMAN

Polyclonal

Rabbit

Mouse

Antigen-specific Affinity Chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

200µg/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB; IHC; ICC

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.

Source: Antibody labeling. Label: Biotin. Traits: Liquid. Immunogen: Recombinant Arg2 (Val23~Ile354) expressed in E.coli.

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2004437

Biotin Antibody

1763758

AAB39855.1

P78540

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Polyamine Biosynthesis, Arginine = Ornithine = Putrescine Pathway (413403); Polyamine Biosynthesis, Arginine = Ornithine = Putrescine Pathway (468321)

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family. Protein type: Mitochondrial; EC 3.5.3.1; Hydrolase; Amino Acid Metabolism - arginine and proline. Chromosomal Location of Human Ortholog: 14q24.1. Cellular Component: mitochondrion; mitochondrial matrix. Molecular Function: metal ion binding; arginase activity. Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle

0.1 mg

250 USD

0.2 mg

380

1 mg

905