Polyclonal Antibody to Thyroxine Binding Globulin (TBG) | MyBioSource MBS2005052 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Thyroxine Binding Globulin (TBG)

catalog :

MBS2005052

quantity :

0.01 mg

price :

105 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Lane1: Human Liver Tissue; Lane2: Human Hela Cells.

image 2 :

Western Blot: Sample: Recombinant TBG, Human.

image 3 :

DAB staining on IHC-P; Samples: Human Liver Tissue

product information

catalog number :

MBS2005052

products type :

Antibody

products full name :

Polyclonal Antibody to Thyroxine Binding Globulin (TBG)

products short name :

[Thyroxine Binding Globulin (TBG)]

other names :

[thyroxine-binding globulin; Thyroxine-binding globulin; thyroxine-binding globulin; serpin family A member 7; Serpin A7; T4-binding globulin]

products gene name :

[TBG]

other gene names :

[SERPINA7; SERPINA7; TBG; TBGQTL; TBG]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.37mg/ml

storage stability :

Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP)

app notes :

Western blotting: 0.5-2 ug/mL;1:190-740. Immunohistochemistry: 5-20 ug/mL;1:19-74. Immunocytochemistry: 5-20 ug/mL;1:19-74. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Human Stomach Tissue.

image5 heading :

Knockout Validation

image5 description :

Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: TBG knockout Hela cell lysate; Predicted MW: 46kd Observed MW: 46kd Primary Ab: 5ug/ml Rabbit Anti-Human TBG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)

other info1 :

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TBG (Leu128~Ala415 (Accession # P05543)) expressed in E.coli

products categories :

Knock-Out Validation Antibody

ncbi gi num :

205277441

ncbi acc num :

NP_000345.2

ncbi gb acc num :

NM_000354.5

uniprot acc num :

P05543

ncbi summary :

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

uniprot summary :

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xq22.3. Cellular Component: extracellular region; extracellular space. Molecular Function: serine-type endopeptidase inhibitor activity. Disease: Thyroxine-binding Globulin Quantitative Trait Locus

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

125

size3 :

0.05 mg

price3 :

165

size4 :

0.1 mg

price4 :

210

size5 :

0.2 mg

price5 :

310

size6 :

1 mg

price6 :

725

more info or order :

MyBioSource product webpage