catalog number :
MBS2004748
products full name :
Biotin-Linked Antibody to Proteinase 3 (PR3)
products short name :
Proteinase 3 (PR3)
other names :
proteinase 3; Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
other gene names :
PRTN3; MBN; PR-3; PR3; NP-4
uniprot entry name :
PRTN3_HUMAN
sequence :
The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF-ALV FGGAVQASKI VGGHEARPHS RPYVASLQLS RSPGSHFCGG TLIHPRFVLT AAHCLQDISW QLVTVVLGAH DLLSSEPEQQ KFTITQVFEN NYNPEETLND VLLLQLNRPA SLGKQVAVAS LPQQDQSLSQ GTQCLAMGWG RLGTRAPTPR VLHELNVTVV TFLCREHNVC TLVPRRAAGI CFGDSGGPLI CNGILHGVDS FVIRECASLQ FPDFFARVSM YVNWIH
specificity :
The antibody is a rabbit polyclonal antibody raised against PR3. It has been selected for its ability to recognize PR3 in immunohistochemical staining and western blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB), ICC, IHC-P, IHC-F
app notes :
Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-200. Optimal working dilutions must be determined by end user.
products categories :
Biotin Antibody
ncbi acc num :
CAA39203.1
ncbi mol weight :
27,807 Da
uniprot summary :
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. Protein type: EC 3.4.21.76; Protease; Cell cycle regulation. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol. Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: collagen catabolic process; negative regulation of phagocytosis; positive regulation of cell proliferation; proteolysis; blood coagulation