antibody

Polyclonal Antibody to Ferroportin (FPN)

MBS2004615

0.01 mg

110 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

Antibody

Polyclonal Antibody to Ferroportin (FPN)

[Ferroportin (FPN)]

[solute carrier family 40 member 1; Solute carrier family 40 member 1; solute carrier family 40 member 1; solute carrier family 40 member 1; Ferroportin-1; Iron-regulated transporter 1]

[FPN]

[SLC40A1; SLC40A1; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3; FPN1; IREG1; SLC11A3]

Polyclonal

Rabbit

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

1 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB; IHC; ICC; IP.

Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL; 1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.

Western Blot (WB)

Immunogen: Recombinant FPN (Trp127~Val321) expressed in E.coli.

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2066090

7657100

NP_055400.1

NM_014585.5

Q9NP59

Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (187191); Metal Ion SLC Transporters Pathway (161066); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: basolateral plasma membrane; cytoplasm; cytosol; integral component of membrane; integral component of plasma membrane; intracellular; nucleoplasm; plasma membrane; synaptic vesicle. Molecular Function: ferrous iron transmembrane transporter activity; iron ion transmembrane transporter activity; peptide hormone binding; protein binding; receptor activity. Biological Process: cellular iron ion homeostasis; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter. Disease: Hemochromatosis, Type 4

0.01 mg

110 USD

0.02 mg

130

0.05 mg

175

0.1 mg

225

0.2 mg

340

1 mg

800