Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | MyBioSource MBS2004372 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

catalog :

MBS2004372

quantity :

0.01 mg

price :

90 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant TIMP1, Mouse.

image 2 :

DAB staining on IHC-P; Samples: Mouse Kidney Cancer Tissue

image 3 :

DAB staining on IHC-P; Samples: Mouse Liver Cancer Tissue.

product information

catalog number :

MBS2004372

products type :

Antibody

products full name :

Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

products short name :

[Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)]

other names :

[metalloproteinase inhibitor 1 isoform a; Metalloproteinase inhibitor 1; metalloproteinase inhibitor 1; tissue inhibitor of metalloproteinase 1; Collagenase inhibitor 16C8 fibroblast; Erythroid-potentiating activity; EPA; TPA-S1; TPA-induced protein; Tissue inhibitor of metalloproteinases 1; TIMP-1]

products gene name :

[TIMP1]

other gene names :

[Timp1; Timp1; EPA; Clgi; Timp; TIMP-1; TPA-S1; Timp; Timp-1; EPA; TIMP-1]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.45 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determinedby accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2 Ug/mL;1:200-900. Immunohistochemistry: 5-20 Ug/mL;1:20-90. Immunocytochemistry: 5-20 Ug/mL;1:20-90. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Mouse Liver Tissue.

other info1 :

Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Immunogen: Recombinant TIMP1 (Ala35~Pro160) expressed in E.coli. Traits: Liquid

ncbi gi num :

113205063

ncbi acc num :

NP_001037849.1

ncbi gb acc num :

NM_001044384.1

uniprot acc num :

P12032

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (1323923); Degradation Of The Extracellular Matrix Pathway (1323922); Extracellular Matrix Organization Pathway (1323909); HIF-1 Signaling Pathway (695223); Hemostasis Pathway (1323559); Matrix Metalloproteinases Pathway (198370); Platelet Activation, Signaling And Aggregation Pathway (1323569); Platelet Degranulation Pathway (1323586); Response To Elevated Platelet Cytosolic Ca2+ Pathway (1323584)

uniprot summary :

TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: X A1.3 X 16.38 cM. Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix. Molecular Function: cytokine activity; enzyme inhibitor activity; growth factor activity; metal ion binding; metalloendopeptidase inhibitor activity; peptidase inhibitor activity; protease binding; zinc ion binding. Biological Process: cell activation; negative regulation of apoptosis; negative regulation of catalytic activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of peptidase activity; positive regulation of cell proliferation; response to cytokine; response to hormone

size1 :

0.01 mg

price1 :

90 USD

size2 :

0.02 mg

price2 :

105

size3 :

0.05 mg

price3 :

140

size4 :

0.1 mg

price4 :

170

size5 :

0.2 mg

price5 :

235

size6 :

1 mg

price6 :

545

more info or order :

MyBioSource product webpage