catalog number :
MBS2003987
products full name :
Polyclonal Antibody to Luteinizing Hormone Beta Polypeptide (LHb)
products short name :
Luteinizing Hormone Beta Polypeptide (LHb)
other names :
luteinizing hormone beta polypeptide; Lutropin subunit beta; lutropin subunit beta; LSH-beta; lutropin beta chain; luteinizing hormone beta subunit; interstitial cell stimulating hormone, beta chain; luteinizing hormone beta polypeptide; Luteinizing hormone subunit beta
other gene names :
LHB; LHB; CGB4; hLHB; LSH-B; Lutropin beta chain; LH-B; LSH-B; LSH-beta
uniprot entry name :
LSHB_HUMAN
specificity :
The antibody is a rabbit polyclonal antibody raised against LHb. It has been selected for its ability to recognize LHb in immunohistochemical staining andwestern blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
app notes :
Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200
other info1 :
Antigen: LHb (Ser21~Phe141)
other info2 :
Quality Control: Content: The quality control contains recombinant Thyroglobulin (Ser2083~Ala2333) disposed in loading buffer. Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate. 5uL per well when used in enhanced chemilumescent (ECL). Note: The quality control is specifically manufactured as the positive control.Not used for other purposes. Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
ncbi acc num :
EAW52432.1
ncbi mol weight :
15,345 Da
ncbi pathways :
Androgen Biosynthesis Pathway (106154); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Glycoprotein Hormones Pathway (160989); GnRH Signaling Pathway (83091); GnRH Signaling Pathway (502); Hormone Ligand-binding Receptors Pathway (106369); Metabolism Pathway (477135)
ncbi summary :
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
uniprot summary :
LHB: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Defects in LHB are a cause of hypogonadism LHB-related (HGON-LHB). Hypogonadism is characterized by infertility and pseudohermaphroditism. Belongs to the glycoprotein hormones subunit beta family. Protein type: Secreted; Hormone; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: extracellular region. Molecular Function: hormone activity; receptor binding. Biological Process: progesterone biosynthetic process; cellular protein metabolic process; cell-cell signaling; male gonad development; peptide hormone processing; signal transduction. Disease: Fertile Eunuch Syndrome