catalog number :
MBS2003610
products full name :
Polyclonal Antibody to Uromodulin (UMOD)
products short name :
[Uromodulin (UMOD)]
other names :
[uromodulin; Uromodulin; uromodulin; uromodulin; Tamm-Horsfall urinary glycoprotein; THP]
products gene name :
[UMOD]
other gene names :
[Umod; Umod; THP; THP]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
concentration :
0.57mg/ml
storage stability :
Storage:. Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, Immunoprecipitation (IP), Western Blot (WB).
app notes :
Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Rattus norvegicus (Rat). Source: Polyclonal antibody preparation
other info2 :
Traits: Liquid. Immunogen: Recombinant UMOD (Glu30~Glu150) expressed in E.coli
ncbi acc num :
NP_058778.1
ncbi gb acc num :
NM_017082.1
ncbi summary :
mutation of the human homolog is associated with medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy [RGD, Feb 2006]
uniprot summary :
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.