product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
Biotin-Linked Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7)
catalog :
MBS2002626
quantity :
0.1 mg
price :
415 USD
clonality :
polyclonal
host :
rabbit
conjugate :
biotin
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2002626
products type :
Antibody
products full name :
Biotin-Linked Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7)
products short name :
A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7)
other names :
A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 7; A disintegrin and metalloproteinase with thrombospondin motifs 7; COMPase; a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7; ADAM metallopeptidase with thrombospondin type 1 motif, 7; COMPase
products gene name :
ADAMTS7
other gene names :
ADAMTS7; ADAMTS7; ADAM-TS7; ADAMTS-7; ADAM-TS 7; ADAM-TS 7; ADAM-TS7; ADAMTS-7
uniprot entry name :
ATS7_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
1686
specificity :
The antibody is a rabbit polyclonal antibody raised against ADAMTS7 conjugated to biotin. It has been selected for its ability to recognize ADAMTS7 in immunohistochemical staining andwestern blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
concentration :
200ug/ml
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
app notes :
Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200
other info2 :
Conjugation: Biotin
products categories :
Biotin Antibody
ncbi gi num :
38683827
ncbi acc num :
NP_055087.2
ncbi gb acc num :
NM_014272.3
uniprot acc num :
Q9UKP4
ncbi mol weight :
184,095 Da
uniprot summary :
Function: Metalloprotease that may play a role in the degradation of COMP. Ref.1. Cofactor: Binds 1 zinc ion per subunit . By similarity. Ref.1. Subunit structure: Interacts with COMP. Ref.1. Subcellular location: Secreted extracellular space extracellular matrix . By similarity. Note: Also found associated with the external cell surface . By similarity. Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments. Ref.1 Ref.4. Induction: Up-regulated in articular cartilage and synovium from arthritis patients. Ref.1. Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. Post-translational modification: N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate. Ref.4May be cleaved by a furin endopeptidase . By similarity. The precursor is sequentially processed. Ref.4. Sequence similarities: Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.Contains 1 PLAC domain.Contains 8 TSP type-1 domains. Biophysicochemical propertiespH dependence:Optimum pH is between 7.5 and 9.5. Sequence caution: The sequence AAD56358.1 differs from that shown. Reason: Probable cloning artifact.
size :
0.1 mg
price :
415 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!