catalog number :
MBS2002309
products full name :
Polyclonal Antibody to Pleiotrophin (PTN)
products short name :
[Pleiotrophin (PTN)]
other names :
[pleiotrophin; Pleiotrophin; pleiotrophin; pleiotrophin; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neutrophic factor; HBNF; Osteoblast-specific factor 1; OSF-1]
products gene name :
[PTN]
other gene names :
[Ptn; Ptn; OSF; HARP; HBBN; HBNF; Osf1; Osf-1; HB-GAM; HBGF-8; PTN; HBBM; HBGF-8; HB-GAM; HBNF; OSF-1]
specificity :
The antibody is a Rabbit polyclonal antibody raised against PTN. It has been selected for its ability to recognize PTN in immunohistochemical staining and western blotting.
purity :
Antigen-specific Affinity Chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP
app notes :
Western blotting: 0.5-2µg/mL. Immunohistochemistry: 5-20µg/mL. Immunocytochemistry: 5-20µg/mL. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant PTN (Gly33~Asp168) expressed in E.coli.
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2053736
ncbi acc num :
NP_032999.1
ncbi gb acc num :
NM_008973.2
ncbi mol weight :
18,869 Da
uniprot summary :
PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6 B1 6 15.48 cM. Cellular Component: basement membrane; cell surface; cytoplasm; endoplasmic reticulum; extracellular region; extracellular space; membrane; neuromuscular junction; perinuclear region of cytoplasm; protein complex; proteinaceous extracellular matrix. Molecular Function: glycosaminoglycan binding; growth factor activity; heparin binding; protein kinase binding; proteoglycan binding. Biological Process: bone mineralization; learning; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of epithelial cell proliferation; negative regulation of membrane potential; ossification; positive regulation of apoptosis; positive regulation of cell division; positive regulation of cell proliferation; regulation of cell shape