product summary
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company name :
MyBioSource
product type :
antibody
product name :
Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2)
catalog :
MBS2002249
quantity :
0.01 mg
price :
135 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
pig
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2002249
products type :
Antibody
products full name :
Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2)
products short name :
Interleukin 12 Receptor Beta 2 (IL12Rb2)
other names :
interleukin-12 receptor subunit beta-2; Interleukin-12 receptor subunit beta-2; interleukin-12 receptor subunit beta-2; IL-12RB2; IL-12R-beta-2; IL-12R subunit beta-2; IL-12 receptor subunit beta-2; interleukin-12 receptor beta 2
products gene name :
IL12Rb2
other gene names :
IL12RB2; IL12RB2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2
uniprot entry name :
I12R2_PIG
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Mouse
sequence length :
861
sequence :
The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF- MVNATN AKGKYDLRDL RPFTEYEFQI SSKLHLSGGS WSNWSESLRT RTPEEEPVGI LDIWYMKQDI DYDRQQISLF WKSLNPSEAR GKILHYQVTL QEVTKKTTLQ NTTRHTSWTR VIPRTGAWTA SVSAANSKGA SAPTHINIVD LCGTGLLAPH Q
specificity :
The antibody is a rabbit polyclonal antibody raised against IL12Rb2. It has been selected for its ability to recognize IL12Rb2 in immunohistochemical staining andwestern blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
concentration :
200ug/ml
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
app notes :
Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200
other info1 :
Immunogen: IL12Rb2, Mouse
other info2 :
Quality Control: Content: The quality control contains recombinant CRP (Phe17~Pro224) disposed in loading buffer. Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate. 5uL per well when used in enhanced chemilumescent (ECL). Note: The quality control is specifically manufactured as the positive control.Not used for other purposes. Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
ncbi gi num :
47523004
ncbi acc num :
NP_999262.1
ncbi gb acc num :
NM_214097.2
uniprot acc num :
Q8MJS1
ncbi mol weight :
96,056 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (84463); Cytokine-cytokine Receptor Interaction Pathway (460); Inflammatory Bowel Disease (IBD) Pathway (842783); Inflammatory Bowel Disease (IBD) Pathway (842797); Jak-STAT Signaling Pathway (84489); Jak-STAT Signaling Pathway (488)
uniprot summary :
Function: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Subunit structure: Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain . By similarity. Subcellular location: Membrane; Single-pass type I membrane protein. Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation. Post-translational modification: On IL12 stimulation, phosphorylated on C-terminal tyrosine residues . By similarity. Sequence similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 5 fibronectin type-III domains.
size1 :
0.01 mg
price1 :
135 USD
size2 :
0.05 mg
price2 :
230
size3 :
0.1 mg
price3 :
310
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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