Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8) | MyBioSource MBS2002216 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8)

catalog :

MBS2002216

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Human Placenta lysate; Primary Ab: 4ug/ml Rabbit Anti-Human LRP8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

image 2 :

Western Blot: Sample: Recombinant protein.

image 3 :

DAB staining on IHC-P. Samples: Human Tissue)

product information

catalog number :

MBS2002216

products type :

Antibody

products full name :

Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8)

products short name :

[Low Density Lipoprotein Receptor Related Protein 8 (LRP8)]

other names :

[low-density lipoprotein receptor-related protein 8 isoform 4; Low-density lipoprotein receptor-related protein 8; low-density lipoprotein receptor-related protein 8; LDL receptor related protein 8; Apolipoprotein E receptor 2]

products gene name :

[LRP8]

other gene names :

[LRP8; LRP8; MCI1; LRP-8; APOER2; HSZ75190; APOER2; LRP-8]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

963

sequence :

Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-PNGGC EYLCLPAPQI SSHSPKYTCA CPDTMWLGPD MKRCYRAPQS TSTTTLASTM TRTVPATTRA ã€€ PGTTVHRSTY QNHSTETPSL TAAVPSSVSV PRAPSISPST LSPATSNHSQ HYANEDSKMG STVTAAVIGI IVPIVVIALL CMSGYLIWRN WKRKNTKSMN FDNPVYRKTT EEEDEDELHI GRTAQIGHVY PAAISSFDRP LWAEPCLGET REPEDPAPAL KELFVLPGEP RSQLHQLPKN P

specificity :

The antibody is a rabbit polyclonal antibody raised against LRP8. It has been selected for its ability to recognize LRP8 in immunohistochemical staining andwestern blotting.

purity :

Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

concentration :

200ug/ml

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

app notes :

Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-5000. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: LRP8, Human. Immunogen Information: Recombinant LRP8 (Pro696~Pro941) with two N-terminal Tags, His-tag and GST-tag expressed in E.coli. Accession No.: RPD099Hu01

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2070005

ncbi gi num :

65301119

ncbi acc num :

NP_001018064.1

ncbi gb acc num :

NM_001018054.2

uniprot acc num :

Q14114

ncbi mol weight :

â€“ Da

ncbi pathways :

Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Hemostasis Pathway (106028); Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); Platelet Homeostasis Pathway (187198); Platelet Sensitization By LDL Pathway (187204); Reelin Signaling Pathway (137980); Retinoid Metabolism And Transport Pathway (187208); Signal Transduction Pathway (477114); Visual Phototransduction Pathway (771584)

ncbi summary :

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

uniprot summary :

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 ().

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

340

size6 :

1 mg

price6 :

800

more info or order :

MyBioSource product webpage