catalog number :
MBS2002182
products full name :
Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)
products short name :
[Bone Morphogenetic Protein 2 (BMP2)]
other names :
[bone morphogenetic protein 2; Bone morphogenetic protein 2; bone morphogenetic protein 2]
products gene name :
[BMP2]
other gene names :
[BMP2; BMP2; BMP-2; BMP-2; BMP-2]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
concentration :
0.41 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).
app notes :
Western blotting: 0.5-2 ug/mL;1:200-800. Immunohistochemistry: 5-20 ug/mL;1:20-80. Immunocytochemistry: 5-20 ug/mL;1:20-80. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
other info1 :
Organism Species: Oryctolagus cuniculus (Rabbit). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant BMP2 (Lys284~Val388) expressed in E.coli
ncbi acc num :
NP_001076119.1
ncbi gb acc num :
NM_001082650.1
ncbi pathways :
Adipogenesis Pathway (198832); BMP Signalling Pathway (545370); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Heart Development Pathway (198802); Hedgehog Signaling Pathway (83063); Hedgehog Signaling Pathway (474); Id Signaling Pathway (198871)
uniprot summary :
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.