catalog number :
MBS200209
products full name :
H5N1/HA1 antibody (clone AT2B7)
products short name :
H5N1/HA1
products name syn :
Hemagglutinin; Influenza A virus (A/Vietnam/HN31242/2007H5N1) haemagglutinin
products gene name :
H5N1/HA1
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:3000. ELISA. H5N1 HA1 Antibody (1 ug/ml) specifically recognizes H5N1/HA1 recombinant protein, but not interacted H1N1/HA1 and H3N2/HA1 recombinant protein in ELISA.
other info1 :
Antigen Species: Influenza A-H5N1. Clone: Anti-human H5N1/HA1 mAb, clone 2B7, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human H5N1/HA1 protein. Immunogen: Recombinant human H5N1/HA1 (17-338aa) purified from Baculovirus
products description :
H5N1 is a subtype of the species Influenza A virus of the Influenzavirus A genus of the Orthomyxoviridae family. consists of single-stranded eight-segment negative-sense genomic RNAs, helical viral ribonucleoprotein (RNP) complexes (RNA segments NP, PB2, PB1 and PA), three viral envelope proteins (hemagglutinin [HA], neuraminidase [NA], and M2 ion channel), and a maxtir (M1) protein. Influenza A viruses are further classified into 16 HA (H1-H16) and 9 NA (N1-N9) serotypes based on the antigenic characteristics of HA and NA envelope glycoproteins. It is responsible for binding the virus to the cell that is being infected. HA protein has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding of these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.
products references :
Song D., et al. (2008) Emerg. Infect. Dis. 14:741-746. Li S., et al. (2010) Infect. Genet. Evol. 10:1286-1288. Horimoto T, Kawaoka Y (2005) Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 3: 591-600.