antibody

Biotin-Linked Antibody to A Disintegrin And Metalloprotease 20 (ADAM20)

MBS2002011

0.1 mg

470 USD

polyclonal

rabbit

biotin

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Biotin-Linked Antibody to A Disintegrin And Metalloprotease 20 (ADAM20)

A Disintegrin And Metalloprotease 20 (ADAM20)

A disintegrin and metalloproteinase with thrombospondin motifs 20 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 20; A disintegrin and metalloproteinase with thrombospondin motifs 20; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20; ADAM metallopeptidase with thrombospondin type 1 motif, 20

ADAM20

ADAMTS20; ADAMTS20; GON-1; ADAM-TS20; ADAMTS-20; ADAM-TS 20; ADAM-TS20; ADAMTS-20

ATS20_HUMAN

Polyclonal

IgG

Rabbit

Human

1910

The antibody is a rabbit polyclonal antibody raised against ADAM20 conjugated to biotin. It has been selected for its ability to recognize ADAM20 in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

200ug/ml

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200

Conjugation: Biotin

Biotin Antibody

124430557

NP_079279.3

NM_025003.3

P59510

214,721 Da

Function: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain. Cofactor: Binds 1 zinc ion per subunit . By similarity. Subcellular location: Secreted extracellular space extracellular matrix . By similarity. Tissue specificity: Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas. Post-translational modification: The precursor is cleaved by a furin endopeptidase . By similarity.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion . By similarity. Sequence similarities: Contains 1 disintegrin domain.Contains 1 GON domain.Contains 1 peptidase M12B domain.Contains 15 TSP type-1 domains.

0.1 mg

470 USD