catalog number :
MBS2001929
products full name :
Polyclonal Antibody to Regenerating Islet Derived Protein 3 Gamma (REG3g)
products short name :
[Regenerating Islet Derived Protein 3 Gamma (REG3g)]
other names :
[regenerating islet-derived protein 3-gamma preproprotein; Regenerating islet-derived protein 3-gamma; regenerating islet-derived protein 3-gamma; regenerating islet-derived 3 gamma; Pancreatitis-associated protein 3; Regenerating islet-derived protein III-gamma; Reg III-gamma]
products gene name :
[REG3g]
other gene names :
[Reg3g; Reg3g; AI449515; REG-3-gamma; reg III-gamma; Pap3; REG-3-gamma; Reg III-gamma]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
form :
Supplied as a solution form in 0.01M PBS,pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze-thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate.The loss rate was determined by accelerated thermal degradation test, that is incucbate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropiate storage condition.
tested application :
WB; IHC; ICC; IP
app notes :
Western blotting: 0.5- 2ug/mL; 1:500-2000. Immunohistochemistry: 5-20 ug/mL;1: 50-200. Immunocytochemistry: 5-:20 ug/mL; 1:50-200. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant REG3g( Arg45-Ser152(Accession#O09049)expressed in E.coli.
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2075039
ncbi acc num :
NP_035390.1
ncbi gb acc num :
NM_011260.2
ncbi pathways :
Antimicrobial Peptides Pathway (1457936); Immune System Pathway (1367472); Innate Immune System Pathway (1367502)
ncbi summary :
This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]
uniprot summary :
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.